Brain in vitro

In studies in Alzheimer s brain, in vitro induction of lipid peroxidation by iron is more intense than in control cortical samples (Andorn et al., 1990 Subbarao et nL, 1990 McIntosh et al., 1991). The 21-aminosteroid U-74500A has been shown to effectively inhibit iron-induced lipid peroxidation in Alzheimer s brain samples (Subbarao et al., 1990). 

Marien, M., Brien, J., and Jhamandas, K., Regional release of [3H]dopamine from rat brain in vitro effects of opioids on release induced by potassium nicotine, and L-glutamic acid, Can. J. Physiol. Pharmacol., 61, 43, 1983. 

Oboh G, Puntel RL and Rocha JBT. 2007. Hot pepper (Capsicum annuum, Tepin and Capsicum Chinese, Habanero) prevents Fe2+-induced lipid peroxidation in brain—in vitro. Food Chem 102(1) 178—185. 

Sodium fluoroacetate (but not methyl fluoroacetate) is practically without action on frog nerve or brain in vitro. The ester decreases the action potential of frog sciatic nerve and reduces the conduction velocity.5 The inactivity of the salt may be related partly to its inability to penetrate cells. 

Bowman PD, Betz AL, Ar D, Wolinsky JS, Penney JB, Shivers RR, Goldstein GW (1981) Primary culture of capillary endothelium from rat brain. In Vitro 17 353-362... 

Compton DR, Bagley RB, Katzen JS, Martin BR. 1987. (-l-)-and (-)-N-aUylnormetazocine binding sites in mouse brain in vitro and in vivo characterization and regional distribution. Life Sci 40 2195-2206. 

In the late 1960s, different types of cyclopropylamines, the A/-substituted cyclopropylamines, were reported [111]. One of the most interesting compounds in the new class was A/-[2-o-chlorophenoxy]-ethyl]-cyclopropylamine (Lilly 51641) (42). This compound noncompetitively inhibited the MAO-catalyzed oxidation of serotonin, tyramine, phenylethylamine, and tryptamine in vitro and increased the serotonin concentration in the whole rat brain in vitro. In structure-activity studies on a series of m- and p-aromatic substituted A/-(phenoxyethyl)cyclopropylamines (43), the degree of inhibition correlated well with a and % values [112]. 

Emson PC, Lee CM, Rehfeld JF Cholecystokinin peptides vesicular localization and calcium dependent release from rat brain in vitro. Life Sci 26 2157-2162, 1980... 

Richelson E, Nelson A Antagonism by neuroleptics of neurotransmitter receptors of normal brain in vitro. Eur J Pharmacol 103 197-204, 1984 Rickels K, Schweizer E The treatment of generalized anxiety disorder in patients with depressive symptomatology. J Clin Psychiatry 54 [suppl) 20-23, 1993 Rickels K, Weisman K, Norstad N, et al Buspirone and diazepam in anxiety a controlled study. J Chn Psychiatry 43(12 pt 2) 81-86, 1982 Rickels K, Feighner JP, Smith WT Alprazolam, amitriptyline, doxepin, and placebo in the treatment of depression. Arch Gen Psychiatry 42 134-141, 1985 Rickels K, Schweizer E, Weiss S, et al Maintenance drug treatment for panic disorder, 11 short- and long-term outcome after drug taper. Arch Gen Psychiatry 50 61-68, 1993... 

On comparison of cholinesterase activities In the brain on various days after gavage with parathlon at 35 mg/kg and after exposure of a homogenate of brain in vitro to 10 M 2-PAM-1, the reactivation accomplished by the oxime was found to decrease progressively as spontaneous reactivation increased ... 

Driessen, B. and Reimann, W. Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro, Br. J. Pharmacol. 1992, 105, 147-151. 

Batrakova, E., et al. 2001. Pluronic P85 enhances the delivery of digoxin to the brain In vitro and in vivo studies. J Pharmacol Exp Ther 296 551. 

Fuller RW, Snoddy HD, Mason NR, Molloy BR. Effect of l-(m-trifluoro-methylphenyl)-piperazine on 3H-serotonin binding to membranes from rat brain in vitro and on serotonin turnover in rat brain in vivo. Eur J Pharmacol 1978 52 11-16. 

Kodavanti PR, Ward TR. Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro. Toxicol Sci. 2005 85 952-962. 

As inhibitors of N-acetyltransferase activity, the formamidines showed a pattern similar to their effect on 0A uptake i.e. CDM was the least active member of the series with DCDM and DDCDM increasingly more active. At 0.25 mM, DDCDM caused about 50% inhibition of NAT activity. Little previous work has been published on N-acetyl transferase inhibitors in insects. However, the inhibition by CDM of NAT acting on tryptamine was reported by Allais et al. (29). They showed that 1.2 mg of CDM applied topically to locusts reduced subsequent NAT activity in the brain in vitro by approximately 35%. 

Bowery NG, Hudson AL, Price GW (1985) Comparative autoradiographic studies with [ H]-GABA and pH]-( -)-baclofen in rat brain in vitro. Br. J. Pharmacol. 85, 234P. 

Table II. Inhibition of Monoamine Oxidase of Rat Brain in Vitro and in Vivo by Amino Acid Isopropylhydrazides as Compared to Iproniazid ...

Benjamin AM, Okamoto K, Quastel JH. 1978. Effects of ammonium ions on spontaneous action potentials an on contents of sodium, potassium, ammonium and chloride ions in brain in vitro. J Neurochem 30 131-143. 

Rodgers, A.D. and Curzon, D. (1975) Melanin formation by human brain in vitro. J. Neurochem. 24 1123-1129. 

Ran, M, R., Kanji, V. K., and Sekhar, V. (1999), Pesticide induced changes of nitric oxide synthase in rat brain in vitro. Drug... 

Tian WM, Zhang CL, Hou SP, Yu X, Cui FZ, Xu QY, Sheng SL, Cui H, Li HD. Hyaluronic acid hydrogel as Nogo-66 receptor antibody delivery system for the repairing of injured rat brain in vitro. J Control Release 2005 ... 

Snodgrass S R and Iversen L L (1973) A sensitive double-isotope derivative assay to measure release of ammo acids from brain in vitro Nature (New BioU, 241, 154-156... 

Choi, B. H. and Lapham, L. W. (1976) Interactions of neurons and astrocytes during growth and development of human fetal brain in vitro. Eyp. Mol. Pathol. 24, 110-125. 

The toxicity of Pb(C2H5)4 was related in vitro to the inactivation of monoamine oxidase, leading to accumulation of serotonin in the rat brain [180] see also [248]. Pb(C2Hs)4 does not inhibit the uptake of 5-hydroxytryptamine into synaptosomes of rat brain in vitro, presumably owing to its nonionic character [424]. 

Vibrio cholerae Tetanotoxin fixed to brain In vitro release Kryzhanovskii fl/., 1974... 

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