HLA and Bone Marrow Transplantation

Allogeneic bone marrow transplantation was first attempted in the 1960s, usually as a last resort for immunodeficiency syndromes when other forms of treatment were unsuccessful. The results were singularly disappointing. In 1970, Bortin (B19) reviewed 203 bone marrow transplants reported in the scientific 

Significance of Graft versus Host Disease IN Bone Marrow Transplantation 

Following extensive research into GVHD, Billingham identified three essential requirements for the condition to occur (B12)  

the graft must contain immunologically competent cells, 

the host must have transplantation antigens sufficiently different from those of the graft for the graft to be recognized as antigenically foreign, and 

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