Bone marrow transplantation pentamidine

Link H, Vohringer HF, Wingen F, Bragas B, Schwardt A, EhningerG. Pentamidine aerosol for prophylaxis of Pneumocystis carinii pneumonia after BMT. Bone marrow transplantation. 1993 May 11 (5) 403-6. 

Complications due to pentamidine administration used in prophylaxis following bone marrow transplantation have been observed [49]. Indeed, aerosolized pentamidine was associated with increased risk of other infections and decreased survival rate. 

Currently, pentamidine in the form of aerosol is used for the prophylaxis of PCP with apparent success [142-144]. Initially no renal side effects were described with its use two reports, however, now raise this pos-sibdity, which suggests that systemic absorption of pentamidine occurs [145, 146]. One of the patients, however, received a previous large dose of TMP-SMZ and only exhibited a mild elevation of serum creatinine, and the other appears to have had concomitant volume depletion caused by severe diarrhea. We have been unable to find additional reports of renal toxicity associated with aerosol pentamidine administration [147]. Likewise, no renal side effects were reported with the use of aerosolized pentamidine for the prophylaxis of PCP in patients who received bone marrow transplants [144]. 

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See also in sourсe #XX -- [ ]

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