Bone transplantation

The merit of Malinin s work is the comparative study of water content of bones by reproducible methods. The measurement of water vapor pressure during the drying cannot be used dirctly to determine the RM, as Malinin correctly states. Measurement of the description rates (DR) provide a means to follow quantitatively the course of desorption drying. The method is described in Section 1.2.2, but cannot be applied in an installation used by Malinin because the condenser cannot be separated from the chamber by a valve. By using the data given in the paper of Malinin it is possible to estimate the freeze drying process of bone transplants as follows ... 

Observations of metabolic cross-correction provided the rationale for cellular replacement, achieved primarily through allogeneic hematopoietic stem cell or bone transplantation (HSCT) (Prasad and Kurtzberg, 2008). More recently, the use of neural stem cells (NSC) implanted in the brain of patients with late-infantile neuronal ceroid lipofuscinosis has been contemplated (Pierret et al., 2008) but there are no reports as yet of its potential efficacy. Within the central nervous system there must be proper integration of donor cells, and differentiation into appropriate cell types. As specialized cell types within the nervous system elaborate neurotransmitters and are involved with conducting electrical impulses, functional differentiation may be a major hurdle for the neurodegenerative LSDs. 

Deformities of virtually any bone can be corrected. Even facial bones that are malformed can be reshaped or replaced to provide a normal face or to correct defects in the oral cavity. Bone transplants from one individual to another are commonplace. The patient who loses a limb from a disease such as cancer can have a normal-appearing prosthesis fitted and can be taught how to use it and attain a near-normal lifestyle. 

Stevens JM, Hilson AJ, Sweny P. Post-renal transplant distal limb bone pain. An under-recognized comphcation of transplantation distinct from avascular necrosis of bone Transplantation 1995 60(3) 305-7. 

Shaded surface display (SSD) Well-suited for visualizing dense tissue, such as bones or bone transplants, but not for soft tissue or tumors of the hypopharynx or larynx... 

Yaszemski MJ (1996) The evolution of bone transplantation molecular, cellular, and tissue strategies to engineer human bone. Biomaterials 7 175-185... 

FIGURE 14.1.26 X-ray photograph of rahhit tihial bone transplanted with bone tumor, 5 weeks after the transplantation, (a) No treatment, (b) A ferrimagnetic glass-ceramic pin was inserted into the medullary canal and placed under an alternating magnetic field for 30 min, 2 weeks after the transplantation. 

Albee, FH. Fundamentals in bone transplantation experience in three thousand bone graft operations. JAMA, 1923, 81, 1429-1432. 

Ulrich Kalus, Helga Muller, Hans Baudisch, Hans-Ju" rgen Birkhahn, Ru" diger von Versen, Arne Hansen 1 and Axel Pruss (2005) A method for the determination of the residual chloroform in defatted cancellous bone transplants. Cell and Tissue Banking 6 71-75. 

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