Biomaterial cell adhesion

Kwon K, Kidoaki S, and Matsuda T. Electrospun nano- to microfiber fabrics made of biodegradable copolyesters Structural characteristics, mechanical properties and cell adhesion potential. Biomaterials, 2005, 26, 3929-3939. 

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Biomatenals with Low Thromhogenicity. Poly(ethylene oxide) exhibits extraordinary inertness toward most proteins and biological macromolecules. The polymer is therefore used in bulk and surface modification of biomaterials to develop antithrombogenic surfaces for blood contacting materials. Such modified surfaces result in reduced concentrations of cell adhesion and protein adsorption when compared to the nonmodified surfaces. 

Specific carbohydrate ligands may be linked to these polymers in order to enhance the cell-adhesion properties of the biomaterial or in order to modify their physicochemical properties. An example is a biomimetic surfactant polymer of a poly(vinylamine) backbone bearing pendant maltoheptose units to increase local hydration and to inhibit non-specific adsorption.102... 

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Thompson MT, Berg MC, Tobias IS et al (2005) Tuning compliance of nanoscale polyelectrolyte multilayers to modulate cell adhesion. Biomaterials 26 6836-6845... 

Specific domains of proteins (for example, those mentioned in the section Organic Phase ) adsorbed to biomaterial surfaces interact with select cell membrane receptors (Fig. 8) accessibility of adhesive domains (such as specific amino acid sequences) of select adsorbed proteins may either enhance or inhibit subsequent cell (such as osteoblast) attachment (Schakenraad, 1996). Several studies have provided evidence that properties (such as chemistry, charge, and topography) of biomaterial surfaces dictate select interactions (such as type, concentration, and conformation or bioactivity) of plasma proteins (Sinha and Tuan, 1996 Horbett, 1993 Horbett, 1996 Brunette, 1988 Davies, 1988 Luck et al., 1998 Curtis and Wilkinson, 1997). Albumin has been the protein of choice in protein-adsorption investigations because of availability, low cost (compared to other proteins contained in serum), and, most importantly, well-documented conformation or bioactive structure (Horbett, 1993) recently, however, a number of research groups have started to examine protein (such as fibronectin and vitronectin) interactions with material surfaces that are more pertinent to subsequent cell adhesion (Luck et al., 1998 Degasne et al., 1999 Dalton et al., 1995 Lopes et al., 1999). 

Fig. 8. Schematic representation of protein-mediated cell adhesion on biomaterial surfaces. Biomaterial surface properties (such as hydrophilicity/hydrophobicity, topography, energy, and charge) affect subsequent interactions of adsorbed proteins these interactions include but are not limited to adsorbed protein type, concentration, and conformation. Changes in protein-surface interactions may alter accessibility of adhesive domains (such as the peptide sequence arginine-glycine-aspartic acid) to cells (such as osteoblasts, fibroblasts, or endothelial cells) and thus modulate cellular adhesion. (Adapted and redrawn from Schakenraad, 1996.)...

C. Protein-Mediated Cell Adhesion on Biomaterial Surfaces... 

Cell adhesion, protein-mediated, on biomaterials, 143-145 Ceramics... 

Endothelial cells, protein-mediated cell adhesion on biomaterials, 143... 

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