Amphiphiles peptide

The structure and composition of peptide amphiphiles are more flexible than those of amphiphilic-peptide. Designed to function as artificial ECM, peptide amphiphiles were in close connection with markers such as RGD in regenerative medicine. RGD is a peptide motif located on the chain of proteins present in the ECM and has been conjugated to a number of gelators to make synthetic and [Pg.138]

Saccharide-based molecular assemblies have become attractive in their potential applications in tissue engineering owing to their intrinsic biocompatibihty. Saccharides and their glyco-conjugates are rich in ECM, and those on the cell surface play essential roles in traducing signals in and out of a cell. [Pg.140]

Compared to peptide-based molecular gels, studies and applications of saccharide-based molecular gels are still limited. Despite their potential as a matrix for cell immobihzation and encapsulation, saccharide-based gelators usually have complex structures, which have limited their application for tissue engineering [48]. [Pg.141]

Although research involving tissue engineering on Hpid-based molecular gel scaffolds may seem hmited at the present time, there exists significant potential for them to be developed into successful cell culture systems. The use of hpids, either as monomer, Hposome, or surface coating, in tissue engineering has provided powerful evidence of their essential roles in guiding cellular development, attachment, and differentiation. [Pg.145]

Sphingosine-l-phosphate (SIP), for instance, a key member of the sphingoHpids, is pivotal in the induction of numerous cellular processes. SIP is involved in the survival, proliferation, and regulation of apoptosis in human embryonic stem cells [71]. Additionally, SIP maintains growth and multipotency of human bone marrow and adipose tissue-derived mesenchymal stem cells (MSCs) [72]. A recent study involving culturing human umbilical cord MSC with cardiomyocytes-conditioned medium supplemented with SIP showed that SIP is able to trigger and potentiate differentiation and maturation of human umbilical cord MSC into cardiomyocytes. [Pg.145]

Niece KL, Hartgerink JD, Donners J et al (2003) Self-assembly combining two bioactive peptide-amphiphile molecules into nanofibers by electrostatic attraction. J Am Chem Soc 125 7146-7147... [Pg.165]

Anderson JM, Andukuri A, Lim DJ et al (2009) Modulating the gelation properties of self-assembling peptide amphiphiles. ACS Nano 3 3447-3454... [Pg.165]

Hartgerink JD, Beniash E, Stupp SI (2001) Self-assembly and mineralization of peptide-amphiphile nanofibers. Science 294 1684—1688... [Pg.165]

Lowik D, Shklyarevskiy 10, Ruizendaal L et al (2007) A highly ordered material from magnetically aligned peptide amphiphile nanofiber assemblies. Adv Mater 19 1191-1195... [Pg.165]

Stendahl JC, Rao MS, Guler MO et al (2006) Intermolecular forces in the self- assembly of peptide amphiphile nanofibers. Adv Fund Mater 16 499-508... [Pg.165]

Niece KL, Czeisler C, Sahni V et al (2008) Modification of gelation kinetics in bioactive peptide amphiphiles. Biomaterials 29 4501 509... [Pg.165]

Beniash E, Hartgerink JD, Storrie H et al (2005) Self-assembling peptide amphiphile nanofiber matrices for cell entrapment. Acta Biomater 1 387-397... [Pg.165]

Yuwono VM, Hartgerink JD (2007) Peptide amphiphile nanofibers template and catalyze silica nanotube formation. Langmuir 23 5033-5038... [Pg.167]

Arnold MS, Guler MO, Hersam MC, Stupp SI (2005) Encapsulation of carbon nanotubes by selfassembling peptide amphiphiles. Langmuir 21 4705 1709. [Pg.43]

Synthetically lapidated peptides possess the self-assembly character of amphiphilic molecules and biological activity of the peptide headgroups. This enables interfaces to be assembled that dehver biofunctionality in a controllable way. Incorporation of peptide amphiphiles in hposomes greatly increases the uptake of synthetic dyes by cells, indicating their potential utility in targeted drag delivery. [Pg.186]

Peptide- amphiphile/ micelle Parallel 8-sheet Nearly any sequence with terminal alkylation Hydrophobic aggregation followed by hydrogen bonding Parallel... [Pg.360]

Figure 14.10 Self-assembly of peptide-amphiphiles into nanofibers (a) a peptide amphi-phile molecule with five distinct regions designed for hydroxyapatite mineralization, (b) a schematic of molecular self-assembly, and (c) a negatively stain transmission electron microscopy image of the nanofibers. Reprinted from Hartgerink et al. (2001). Copyright 2001 American Association for the Advancement of Science.

Bull SR, Guler MO, Bras RE, Meade TJ, Stupp SI. Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents. Nano Lett 2005 5 1-4. [Pg.388]

Guler MO, Soukasene S, Hulvat JF, Stupp SI. Presentation and recognition of biotin on nanofibers formed by branched peptide amphiphiles. Nano Lett 2005 5 249-252. [Pg.389]

Hung AM, Stupp SI. Simultaneous self-assembly, orientation, and patterning of peptide-amphiphile nanofihers by soft lithography. Nano Lett 2007 7 1165-1171. [Pg.389]

Jiang H, Stupp SI. Dip-pen patterning and surface assembly of peptide amphiphiles. Langmuir... [Pg.389]

Jun H-W, Yuwono V, Paramonov SE, Hartgerink JD. Enzyme-mediated degradation of peptide-amphiphile nanofiber networks. Adv Mater 2005 17 2612-2617. [Pg.389]

Paramonov SE, Jun H-W, Hartgerink JD. Self-assembly of peptide-amphiphile nanofibers the roles of hydrogen bonding and amphiphilic packing. J Am Chem Soc 2006 128 ... [Pg.391]

Sone EDS, Samuel I. Semiconductor-encapsulated peptide-amphiphile nanofibers. J Am Chem Soc 2004 126 12756-12757. [Pg.392]

Tovar JD, Claussen RC, Stupp SI. Probing the interior of peptide amphiphile supramolecular aggregates. J Am Chem Soc 2005 127 7337-7345. [Pg.392]

Fig. 2 The structure of (a) 20 natural L amino acids and (b) aromatic residues that gives rise to (c) aromatic peptide amphiphiles, which form supramolecular polymers through hydrogen bonding and 71-stacking interactions...

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