Cell adhesion control

Normal version (proto-oncogene) is usually involved in promoting cell growth/proliferation Normal version of gene is typically involved in controlling ceU proliferation (e.g., ceU cycle control, cell adhesion control)... 

Byambaa, B. Konno, T. Ishihara, K. Cell adhesion control on photoreactivephospholipid polymer surfaces. Colloids Surf., S2012, 99, 1-6. 

Suzuki, Y, Kusakabe, M., Kaibara, M., Iwaki, M., Sasabe, H., and Nishisaka, T., Cell adhesion control by ion implantation into extra-cellular matrix, Nucl. Instrum. Methods Phys. Res., B9I, 588-592 (1994). 

ELECTRIC FIELD-MEDIATED CELL ADHESION CONTROL... 

Reddy, T. T., Kano, A., Maruyama, A., Hadano, M., Takahara, A. (2(X)8). Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control. Biomacromolecules, 9,1313-1321. 

AQPO, formerly known as the Major Intrinsic Protein of 26 kDa (MDP26), is specifically expressed in the plasma membrane of eye lens fiber cells. It transports water to a low degree, but has also been implicated in cell adhesion and gap junction formation. Its main role is to maintain the transparency of the lens by maintaining a tight cellular connection to neighboring cells and/or by controlling the fluid circulation. 

Ras is a G protein that cycle between two conformations, an activated Ras-GTP or inactivated form Ras-GDP. Ras, attached to the cell membrane by lipidation, is a key component in many signalling cascades, which couple growth factor receptors to downstream effectors that control such processes as cytoskeletal integrity, proliferation, cell adhesion, apoptosis and cell migration. Mutations and dysregulations of the Ras protein leading to increased invasion and metastasis, and decreased apoptosis are very common in cancers. 

Cell Adhesion Molecules Cell-cycle Arrest Cell Cycle Checkpoints Cell Cycle Control Cell Division Cycle Cell Multiplication Cell Proliferation Cellular Immmunity Central Core Disease (CCD)... 

In summary, none of the individual components necessary for recombinant resilin curing were cytotoxic, and there were no leachables from the cured resilin that caused cell death. The cured resilin polymer was not a good surface for cell adhesion, but cells can survive and proliferate in the resilin on a gelatine bead. The curing of recombinant resilin in the presence of cells on beads has no effect on the cells ability to migrate and proliferate with new tissue formation. The resilin is seen to degrade with time, but it is believed that this could be controlled by the type and extent of cross-linking. 

Wick T, Kaye N, Jensen W. Unusually large von Willebrand factor multimers increase adhesion of sickle erythrocytes to human endothelial cells under controlled flow. N Engl J Med 1982 337 1584-1590. 

We investigated the efficiency of NSC expansion on surfaces with EGF-His immobilized in the correct orientation. NSCs were obtained from neurosphere cultures prepared from fetal rat striatum harvested on embryonic day 16. NSCs were cultured for 5 days on EGF-His-immobilized substrates prepared with mixed SAMs of different COOH-thiol contents. Cells adhered and formed network structures at a density that increased with the COOH-thiol content of the surface. As a control, cells were seeded onto surfaces without immobilized EGF-His. This resulted in poor cell adhesion during the entire culture period. In addition, when EGF-His adsorbed to SAMs with 100% COOH-thiol or SAMs with NTA-derivatized COOH that lacked Ni2+ chelation, we observed poor initial cell adhesion, and the cells formed aggregates within 5 days. Interestingly, the substrate used to covalently immobilize EGF-His with the standard carbodiimide chemistry was not a suitable surface for cell adhesion and proliferation. The control experimental results contrasted markedly with results from EGF-His-chelated surfaces. 

Keselowsky BG, Collard DM, Garcia AJ (2003) Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion. J Biomed Mater Res 66A 247-259... 

Calpactins calectrin Calpain Calsequestrin Membrane-binding proteins (365) Protease controlling cell adhesion (366) Sequesters calcium within the sarcoplasmic reticulum when muscles relax (80,367)... 

In order to achieve the firm fixation of the artificial cornea to host tissues, composites of collagen-immobilized poly(vinyl alcohol) hydrogel with hydroxyapatite were synthesized by a hydroxyapatite particles kneading method. The preparation method, characterization, and the results of corneal cell adhesion and proliferation on the composite material were studied. PVA-COL-HAp composites were successfully synthesized. A micro-porous structure of the PVA-COL-HAp could be introduced by hydrochloric acid treatment and the porosity could be controlled by the pH of the hydrochloric acid solution, the treatment time, and the crystallinity of the HAp particles. Chick embryonic keratocyto-like cells were well attached and proliferated on the PVA-COL-HAp composites. This material showed potential for keratoprosthesis application. Further study such as a long-term animal study is now required [241]. 

SECs, like the vascular endothehum, play an active part in the control of leucocyte recruitment in cases of acute and chronic inflammatory conditions. Eeucocyte recruitment from the blood compartment is a crucial determinant for the induction of immunity and inflammation. SECs control this process by producing cytokines that activate leucocytes and by expressing adhesion molecules. Under inflammatory conditions upregulation of intracellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) was found [35 36], as well as expression of E-selectin and P-selectin [37]. Together with the expression of CD4 on SECs it has been postulated that these adhesion molecules might also be involved in the adhesion of KC cells to the sinusoidal wall [20]. 

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