Bioactive compounds anti-inflammatory activity

Both avarol and avarone inhibit replication of the ethiological agent of acquired immuno-deficiency syndrome (AIDS) [77], Additionally, avarol and avarone effectively control acute inflammation in experimental models after either oral or topical administration. Their anti-inflammatory activity may result from inhibition of eicosanoid release and depression of superoxide generation in leukocytes [78], Several studies reviewed the structures and bioactivity of compounds related to avarone as an antihuman immuno-deficiency virus (HIV), antitopoisomerase II activity and as proteinkinase C (PKC) inhibitors [3, 79],... 

Chemical characterization and biological activities of compounds found in this genus are reviewed by Goren and co-workers. Contreras and co-workers have described bioactive components of Bupleurum rigldum L. subscp. rlgidum, some of which have shown interesting anti-inflammatory activity. 

Polyphenols, such as curcumin, quercetin and resveratrol, are some examples of naturally occurring phytochemicals with proven antioxidant and anti-inflammatory activity, beneficial cardiovascular effects," antiatherosclerotic effects, chemopreventive, and anticarcinogenic effects. An abundance of mechanistic information has become available on how polyphenols derived from dietary sources, which have putative chemopreventive properties, interfere with tumor promotion and progression. The effect of these bioactive compounds on the organism is influenced by their bioavailability, namely, their ability to be effectively absorbed by the human body. However, the polyphenols have a poor bioavailability and are rapidly metabolized by human body, losing their potential beneficial effects. ... 

Benslimane, A.F., Pouchvis, Y.F., Verbist, J.-F., Petit, J.-Y., Khettab, E. N., Welin, L., and Brion, J.D. (1992) Marine bioactive compounds stereospedfic anti-inflammatory activity of natural and synthetic cordiachromene A./. Clin. Pharmacol., 32, 37-40. 

Boonphong S, Puangsombat P, Baramee A, Machidol C, Ruchirawat S, Kittakoop P. (2007) Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory and cytotoxic activities. J Nat Prod 70 795-801. 

Great amount of marine fish species have been identified with potential nutraceutical and medicinal values. Consequently, a number of bioactive compounds have been identified including fish muscle proteins, peptides, collagen and gelatin, fish oil, fish bone. Bioactive peptides derived from various fish muscle proteins have shown various biological activities including antihypertensive, antibacterial, anticoagulant, anti-inflammatory, and antioxidant activities, and hence they may be a potential material for biomedical and... 

Bugula neritina) and related organisms produce substances with antibacterial, antitumor (e.g. bryostatins, didemnin B, dolastatin, girodazol, halichondrin B), anti-inflammatory (e.g. pseudopterosin E, manoalide derivatives), antifungal, antiviral, or immuno-suppressive (e.g. microcolin A and B) activity [399,400]. These compounds and/or their synthetic derivatives may be important novel bioactive pharmaceutical substances. It is also very Hkely that some new natural marine substances or their derivatives can be used as antifouling compounds, insecticides, or fungicides. 

Members of the family Amaryllidaceae are widely distributed iir the tropics atrd the warm parts of the temperate regions of the world. They are known for their ornamental value and the production of structurally rmique alkaloids, the Amaryllidaceae alkaloids. Some of these alkaloids possess a wide range of biological activities including antitumor, antiviral, antibacterial, antimalarial, central nervous system diseases, immunomodulatory and anti-inflammatory. This chapter emphasizes the bioactivity and bioactive compounds of African Amaryllidaceae. 

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