Marine bioactive compounds

POLYCYCLIC AMINE ALKALOIDS (3-ALKYLPIPERIDBVE ALKALOIDS) - NOVEL MARINE BIOACTIVE COMPOUNDS STRUCTURE, SYNTHESIS AND BIOCHEMICAL ASPECTS... 

MARINE BIOACTIVE COMPOUNDS FOR POTENTIAL COSMECEUTICAL APPLICATIONS... 

Rodriguez, J. (2000) Polycyclic amine alkaloids (3-alkylpiperidine alkaloids) novel marine bioactive compounds structures, synthesis and biochemical aspects, in Studies in Natural Products Chemistry, vol. 24 (ed. Atta-ur-Rahman), Elsevier, pp. 573—681. 

Benslimane, A.F., Pouchvis, Y.F., Verbist, J.-F., Petit, J.-Y., Khettab, E. N., Welin, L., and Brion, J.D. (1992) Marine bioactive compounds stereospedfic anti-inflammatory activity of natural and synthetic cordiachromene A./. Clin. Pharmacol., 32, 37-40. 

Bioluminescence can be used for spedfic detection of separated bioactive compounds on layers (BioTLC) [46]. After development and drying the mobile phase by evaporation, the layer is coated with microorganisms by immersion of the plate. Single bioactive substances in multicomponent samples are located as zones of differing luminescence. The choice of the luminescent cells determines the specificity of detection. A specific example is the use of the marine bacterium Vibrio fischeri with the BioTLC format. The bioluminescence of the bacteria cells on the layer is reduced by toxic substances, which are detected as dark zones on a fluorescent background. BioTLC kits are available from ChromaDex, Inc. (Santa Ana, CA). 

Sims JJ, Lin GHY, Wing RM (1974) Marine natural products. X. Elatol, a halogenated sesquiterpene alcohol from the red alga Laurencia elata. Tetrahedron Lett 39 3487-3490 Singh S, Kate BN, Banerjee UC (2005) Bioactive compounds from cyanobacteria and microalgae an overview. Crit Rev Biotechnol 25 73-95... 

The study of marine natural products has great possibilities for new products. Thus, Paul Scheuer from Hawaii studied bioactive compounds from mollusks and other marine sources. Luigi Minale, Raffaele Riccio and Maria lorizzi from Italy, conducted a comprehensive research on marine steroidal glycosides. Joel Kashman from Tel-Aviv University investigated on the biologically active natural products from marine organisms. 

Within the operationally defined marine bacteria , i.e., bacteria isolated from marine samples on marine media, bioactive compounds have been reported from Pseudoalteromonas, Cytophaga, Alteromonas, Micrococcus, Bacillus, Acinetobacter, Agrobacterium and Pseudomonas or from unidentified bacteria (Fig. 2). 

Within the network Marine Biotechnology in Lower Saxony [29] an integrated approach between research groups in microbiology, natural product chemistry, biotechnology, and medicine is underway to systematically explore the metabolic capabihties of North Sea bacteria for the production of bioactive compounds with respect to their phylogenetic position. 

A number of triterpenoids are bioactive compounds and are used in medicine. For example, fusidic acid is an antimicrobial fungal metabolite, isolated from Fusidium coccineum, and cytotoxic dimeric triterpenoids, crellastatins, are isolated from marine sponges Crella species. 

Kim, S. K. and Mendis, E. (2006). Bioactive compounds from marine processing byproducts—A review. Food Res. Int. 39,383-393. 

Marine organisms represent a valuable source of nutraceuticals and functional compounds. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of novel active substances for the development of bioactive products. Recently, a great deal of interest has been expressed in marine-derived bioactive peptides because of their numerous beneficial health effects. Moreover, several studies have reported that marine bioactive peptides can be used as... 

Bioactive Compounds from Marine Sponges and Their Symbiotic Microbes A Potential Source of Nutraceuticals... 

Thousands of bioactive compounds that have fascinating potentials to develop as nutraceuticals have been identified from marine sources. This chapter investigates the possibility of developing nutraceuticals from bioactive compounds, identified from marine sponges and symbiotic microorganisms. 

Higa, T, Tanaka, J., Kitamura, A., Koyama, T., Takahashi, M., and Uchida, T. (1994). Bioactive compounds from marine sponges. Pure Appl. Chem. 66, 2227-2230. 

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