Immuno deficiency virus

Tan, G. T., Pezzuto, J. M., Kinghorn, A. D. and Hughes, S. H. 1991. Evaluation of natural products as inhibitors of human immuno deficiency virus type 1 (HIV-1) reverse transcriptase. Journal of Natural Products, 54 143-154. 

Both avarol and avarone inhibit replication of the ethiological agent of acquired immuno-deficiency syndrome (AIDS) [77], Additionally, avarol and avarone effectively control acute inflammation in experimental models after either oral or topical administration. Their anti-inflammatory activity may result from inhibition of eicosanoid release and depression of superoxide generation in leukocytes [78], Several studies reviewed the structures and bioactivity of compounds related to avarone as an antihuman immuno-deficiency virus (HIV), antitopoisomerase II activity and as proteinkinase C (PKC) inhibitors [3, 79],... 

Tuerk, C., Macdougal, S. and Gold, L. (1992) RNA pseudoknots that inhibit human immuno-deficiency virus type-1 reverse transcriptase. Proc. Natl. Acad. Sci. USA, 89, 6988-6992. 

Its mode of action seems to be along these lines. When the thin skin layers and mucus of the mouth, anus or vagina are damaged then, as in all cell damage, there is a large influx of white cells to combat any possible invaders. It is precisely this gathering of white cells, normally effective for killing off viruses or bacteria, that HIV (Human Immuno-deficiency Virus) attacks and takes over. 

Heterogeneous HIV Homogeneous Two materials not in the same physical state. Human Immuno-deficiency Virus. Two or more substances in the same state, e.g. gin and tonic or whiskey and soda ... 

Figure 16.2 shows the results of comparisons of sequences of the aspartic proteinase family of enzymes. It includes pepsins from eukaryotic sources and pro-teinases from retroviruses like human immuno-deficiency virus, HIV. The retroviral proteinases consist of two identical subunits, whereas the pepsins have a single chain with two similar halves, the amino-terminal and the carboxyl-terminal domains, whose structures resemble each other and the subunits of the retroviral proteinases. The sequences of the two domains of the pepsins and the subunits of retroviral proteinases were aligned using COMPARER. Only three residues are identical in all the... 

Boyer J.D., A.D. Cohen, S. Vogt, K. Schumann, B. Nath, L. Ahn, K. Lacy et al. 2000. Vaccination of sero negative volunteers with a human immuno deficiency virus typel env/revDNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines./. Infect. Dis. 181(2) 476-483. 

MacGregor R.R., J.D. Boyer, K.E. Ugen, K.E. Lacy, S.J. Gluckman, M.L. Bagarazzi, M.A. Chattergoon et al. 1998. First human trial of a DNA-based vaccine for treatment of human immuno deficiency virus typel infection Safety and host response. J. Infect. Dis. 178 92-100. 

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