BDNF brain derived neurotrophic

BDNF (brain-derived neurotrophic factor) is a neuro-trophin, i.e. a target-derived growth factor, which is expressed in the brain predominantly in the hippocampus. It acts through its tyrosine kinase receptor, trkB,... 

FIGURE 2 7-2 Neurotrophin receptors. Neurotrophin family members bind specifically to cognate Trk receptors. The low affinity neurotrophin receptor, p75, promiscuously binds all neurotrophins. BDNF, brain-derived neurotrophic factor NGF, nerve growth factor NT, neurotrophin. 

AA arachidonic acid BDNF brain-derived neurotrophic factor... 

BDNF, brain-derived neurotrophic factor DAT, dopamine transporter DRD, dopamine receptor MAOA, monoamine oxidase A MB-catechol-O-methyltransferase QM-MSP, quantitative multiplex methylation-specific polymerase chain reaction RELN, reelin TH. These primers are suitable for QM-MSP. 

Figure 2.8. Scheme of a chimeric peptide with examples for each of the distinct domains. 0X26, anti-rat transferrin receptor monoclonal antibody (mAh) 84-15, anti-human insulin receptor mAh cHSA, cationized human serum albumin VIP, vasoactive intestinal polypeptide DALDA, dermorphin analogue NGF, nerve growth factor BDNF, brain-derived neurotrophic factor PNA, peptide nucleic acid (3-gal, (3-galactosidase. 

AC VIII, adenylyl cyclase type VIII BDNF, brain-derived neurotrophic factor CamKII, calcium-calmodulin kinase II GIRK2, G protein-activated inward rectifying potassium 2 MAOA, monoamine oxidase A n.d., not determined NCAM, neural cell adhesion molecule nNOS, neuronal nitric oxide synthase Petl, ETS domain transcription factor tPA, serine protease tissue-plasminogen activator (tPA). t/ > Increase/decrease in anxiety-related behavior. No effect. 

BBB, blood brain barrier BBI, Bowman-Birk serine protease inhibitor BB-R, bombesin receptor BChE, butyryl cholinesterase BDNF, brain-derived neurotrophic factor BDNF-RTK, brain-derived neurotrophic factor receptor tyrosine kinase aBgTX, a-bungarotoxin BKAS, (3-ketoacyl-ACP synthase BK-R, bradykinin receptor BZ-R, benzodiazepine receptor... 

BDNF brain derived neurotrophic factor is a member of the nerve growth factor family of trophic factors. In the brain, BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994). 

BDNF Brain derived neurotrophic factor (BDNF) plays a crucial role in... 

BDNF Brain-derived neurotrophic factor rs7127507, rsl967554, rsll030118, rs988748, rs2030324, rsll030119, rs2239622 Opioids Methadone... 

Abbreviations ACTH, adrenocorticotropic hormone BDNF. brain-derived neurotrophic factop I GI epidermal growth factop Epo, erythropoietin I SII follicle-stimulating hormone IGI -I insulin-like growth factor-I IL. interleukin NGF, nerve growth factop NT-3, neurotrophin-3 IGI -/fl Transforming growth factor-jSl ft 11 thyrotropin releasing hormone I SI I thyrotropin. Blockade of interleu-kin-2-dependent GPI hydrolysis. 

DSM-IV diagnostic and statistical manual of mental disorders MR, mentally retarded Ml, muscarinic M BDNF, brain-derived neurotrophic factor PV, paraventricular nucleus. 

Fig. 4 Location of cholinergic deficits in the autistic brain (BDNF brain-derived neurotrophic...

Figure 2 Release of BDNF from synthetic microspheres. Microspheres composed of poly-(D,L-lactic-co-glycolide) were engineered to release BDNF over a sustained period. The release of total protein was measured by protein assay and ELISA. There is an initial burst of release over the first 48 hours, followed by sustained release of nanogram quantities for up to 28 days. Abbreviations . BDNF, brain derived neurotrophic factor ELISA, enzyme linked immunosorbent assay.

In addition, neurotrophins bind to a distinct receptor called p75 either alone or in combination withTrks. NGF = nerve growth factor BDNF = brain-derived neurotrophic factor ... 

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