Bradykinin BI receptor

Note of worth is also the successful replacement of the methyl ester with oxime ethers and Af-methoxy imidoyl nitrile in the design of muscarinic agonists (Figure 15.28). Several 1,2,4-oxadiazoles and the other five-mem-bered heterocycles are employed also for other therapeutic indications like monoamine transporter and opioid receptors,5-HT agonists, bradykinin Bi receptor antagonists, and vascular endothelial growth factor receptor (VEGFR-2) inhibitors. ... 

HT agonists, bradykinin Bi receptor antagonists,and vascular endothelial growth factor receptor (VEGFR-2) inhibitors. 

Bradykinin Bi receptor antagonists with high oral bioavailability and minimal PXR activity... 

---