B-cell growth factor

Fibroblast activating factor B-cell growth factor Prostaglandins... 

B cell growth factor T cell growth factor II mast cell growth factor II IL-4... 

Although the mechanism of action of IFN-a against HCL is incompletely understood, it most likely relates to IFN-a-induced B-cell differentiation, inhibition of hairy-cell responsiveness to B-cell growth factors, or activation of antineoplastic immune cell function [83]. 

Interleukin-2 (T-cell growth factor Fig. 30-6A) is secreted by some activated T-lymphocytes. This 133-residue largely helical protein is involved in generation of cytotoxic T-cells, stimulation of interferon release, and of release of a B-cell growth factor.269 Considerable excitement has accompanied the possibility of activating lymphocytes with IL-2 produced from cloned genes in bacteria to increase their ability to kill cancer cells. However, IL-2 is toxic, and this is limiting its use. See also Chapter 31, Section C. 

F4. Ford, R., Tamayo, A., Martin, B., Niu, K., Claypool, K., Cabanillas, F., and Ambrus, J., Jr., Identification of B-cell growth factors (interleukin-14 high molecular weight-B-cell growth factors) in effusion fluids from patients with aggressive B-cell lymphomas. Blood 1, 283—293... 

Emura, M., Nagai, S., Takouchi, M., Kitaichi, M. and Izumi, T. (1990). In vitro production of B-cell growth factor and B-cell differentiation factor by peripheral blood mononuclear cells and bronchoalveolar lavage T lymphocytes from patients with idiopathic pulmonary fibrosis. Clin. Exp. Immunol. 82, 133-139. 

B-cell differentiation factor 2 interleukin-6. B-cell growth factor 1 interleukin-4. 

IL-4 has been formerly known as B-ceU difterentiating factor (BCDF), B-cell growth factor I (BCGF-I), B-cell stimulating factor I (BSF-I), MCGF-II, and T-cell growth factor II (TCGF-II). 

IL-5 was formerly known as BCDF B-cell differentiation factor for IgM (BCDF Ll), B-cell growth factor II (BCGF-II), eosinophil colony stimulating factor, eosinophil differentiation factor, IgA-enhancing factor, and T-cell replacing factor (TRF). ... 

IL-7 was formerly known as lymphopoietin 1 (LP-1), B-cell growth factor, and pre-B cell growth factor. 

IL-14 is unrelated to any other cytokines but shares homology with complement factor Bb. It is a B-cell growth factor produced by T cells (483AA). 

IL-4 TFI cells T- and B-cell growth factor promotes IgE reactions... 

Purification and Biochemical Properties of IL-2. Early approaches to the purification of IL-2 involved classical preparative and chromatographic methods coupled with a search for T cell lines which did not produce other factors (such as colony stimulating factor, B cell growth factors, lymphocyte activating factor). IL-2 from the cloned human leukemia T-cell line JURKAT has been used for purification and... 

IL-4 T cells (Th), mast cells, B cells B-cell growth factor induces proliferation/differentiation of B cells and secretion of IgA, IgGj, and IgE promotes T-cell growth activates macrophages... 

Interleukin-7 (IL-7, pre-B-cell growth factor) is playing its role not only as immunomodulator but also in the beginning of development. IL-7 in together with IL-8 inhibited the gamete interaction of hamster egg and sperm (Lambert et al. 1992). The role of... 

Interleukin 2 is a protein of Af, 15,500 produced by T-cells, which induces the proliferation of T-cells, but only those which have been antigenically stimulated. B-cell growth factor (BCGF) is product by activated T-cells. It stimulates proliferation of B-cells, but not their differentiation to the antibody-producing state. For this, additional L. are required. [XL.Marx Science 221(1983) 1362-1364.]... 

In addition to the prominent role of IL-4, it has been postulated that IL-5 (B-cell growth factor) and IL-6 (B-cell differentiation factor) may have a role in the... 

DeKruyff RH, Turner T, Abrams JS, PaUadino MA, Jr., Umetsu DT. Induction of human IgE synthesis by CD4+ T cell clones. Requirement for interleukin 4 and low molecular weight B cell growth factor. J Exp Med 1989 170 1477-1493. 

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