Asthma/allergy drugs

The sulfonamides are used with caution in patients with renal or hepatic impairment and bronchial asthma. These drugs are given with caution to patients with allergies. Safety for use during pregnancy has not been established (Pregnancy Category C, except at term). 

Brass EP. Implications of a switch from prescription to over-the-counter status for allergy drugs. Curr Allergy Asthma Rep. 2004 4 245-250. 

New Drugs for Asthma, Allergy and COPD, Vol 31,Karger, Basel, 2001, p. 293. 

Clq binding test activity (%) Aspirin-induced asthma Controls Drug allergy... 

Atopu - The immunologic disorders caused by IgE antibodies, colloquially referred to as "allergies." Examples are hay fever, certain forms of asthma and drug hypersensitivities (e.g., "penicillin allergy"). 

Li L, Li Y, Reddel SW, Cherrian M, Friend DS, Stevens RL, Krilis SA. Identification of basophilic cells that express mast cell granule proteases in the peripheral blood of asthma, allergy, and drug-reactive patients. J Immunol 1998 161 5079-5086. 

Penicillins should be used cautiously in patients witii renal disease, pregnancy (Pregnancy Category C), lactation (may cause diarrhea or candidiasis in die infant), and in tiiose witii a history of allergies. Any indication of sensitivity is reason for caution. The drug is also used witii caution in patients witii asthma, renal disease, bleeding disorders, and gastrointestinal disease. 

These drags are contraindicated in patients with an allergy to the (3 blockers, in patients with sinus bradycardia, second- or third-degree heart block, heart failure, and those with asthma, emphysema, or hypotension. The drug are used cautiously in patients with diabetes, thyrotoxicosis, and peptic ulcer. 

In patients with chronic asthma, question the patient concerning allergies, frequency of attacks, severity of attacks, factors that cause or relieve attacks, and any antiasthma drugs used currently or taken previously. 

Anon. Part 1 Executive summary of disease management of drug hypersensitivity a practice parameter. Ann Allergy Asthma Immunol 1999 83 665-700. 

Gather patient history. Assess factors involved in drug selection. Inquire about social history and alcohol use. Ask the patient about drug allergies and chronic health problems such as asthma. 

Erin EM, Williams TJ, Barnes PJ, Hansel TT. Eotaxin receptor (CCR3) antagonism in asthma and allergic disease. Curr Drug Targets Inflamm Allergy 2002 1(2) 201-214. 

Prakash O, Kumar R, Rahman M, Gaur SN. (2006) The clinico-physiological effect of inhaled tiotropium bromide and inhaled ipratropium bromide in severe chronic obstructive pulmonary disease. Ind J Allergy Asthma Immunol 20 105-111 For further information http //www.rxlist.com/spiriva-drug.htm (accessed on 24.12.2010). 

Initial observations on khellin (32), a furochromone-type compound from Ammi visnaga L., showed a mast-cell stabilizing effect. This led to the synthesis of many derivatives of this lead for the potential treatment of allergy and asthma, most notably the approved preventive antiasthma drug, cromolyn sodium (33). The precise molecular mechanism of this class of drugs is not yet clearly imderstood. ... 

Sinus problems, hay fever, bronchial asthma, hives, eczema, contact dermatitis, food allergies, and reactions to drugs are all allergic reactions associated with the release of histamine and other autocoids, such as serotonin, leukotrienes, and prostaglandins. Histamine release is frequently associated with various inflammatory states and may be increased in urticarial reactions, mastocytosis, and basophilia. Histamine also acts as a neurotransmitter in the central nervous system (CNS). Upon release from its storage sites, histamine exerts effects ranging from mild irritation and itching to anaphylactic shock and eventual death. 

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