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Ammi visnaga

Ammi visnaga is a plant of the Umbelliferae family, which has been known and used for its therapeutic properties by the peoples of the Mediterranean basin since time immemorial. [Pg.1588]

By extraction from Ammi visnaga L. (Umbelliferac) and chromatographic purification. Reference(s) ... [Pg.2181]

One should not lightly dismiss the importance of serendipity in the history of drug discovery. In this context, the tale of the antiallergy drug Intal is particularly interesting [1], The toothpick plant (Ammi visnaga) originates in the... [Pg.121]

Initial observations on khellin (32), a furochromone-type compound from Ammi visnaga L., showed a mast-cell stabilizing effect. This led to the synthesis of many derivatives of this lead for the potential treatment of allergy and asthma, most notably the approved preventive antiasthma drug, cromolyn sodium (33). The precise molecular mechanism of this class of drugs is not yet clearly imderstood. ... [Pg.26]

The furanochromone khellin (43) from the seeds of Ammi visnaga is a coronary vasodilator, and it has long been used in Egypt as a spasmolytic to relieve renal colic and ureteral spasms due to schistosomiasis. The corresponding dihydroxy compound is also a vasodilator, but other related compounds are inactive (5lCRV(48)543). [Pg.151]

Disodium cromoglycate (724), marketed as Intal or Cromolyn Sodium, bears some structural resemblance to khellin (457), the spasmolytic component of seeds of Ammi visnaga. Intal is one of the more successful drugs for the prevention of asthmatic attacks, though it is not effective in the treatment of an acute attack of asthma. It appears to prevent the release of histamine and other substances which mediate hypersensitivity reactions but is ineffective once these substances have been released. The chemistry and pharmacology of Intal have been reviewed (B-70MI22402). [Pg.882]

The dried ripe fruits of Ammi visnaga (Umbelliferae/Apiaceae) have a long history of use in the Middle East as an antispasmodic and for the treatment of angina pectoris. The drug contains small amounts of coumarin derivatives, e.g. visnadin (Figure 3.40) (compare Ammi majus, a rich source of furocoumarins, page 146), but the major constituents (2-4%) are... [Pg.75]

Furanochromones (furan [ Phe y-pyran-4-one) have a furan ring fused with the benzene moiety of the chromone. Khellin, the related khellol glucoside and visnagin (dehydrokhellin) derive from seeds of Ammi visnaga (Apiaceae), both khellin and visnagin being phototoxic and vasorelaxant cAMP phosphodiesterase inhibitors. [Pg.27]

Visnadin (= Cardine Ammi visnaga, Anethum sp., Ca 1 CH [coronary... [Pg.150]

Ammi visnaga, Anethum graveolens (Apiaceae), TAonysia spp., Primula pulverulmta (Primulaceae) [leaf], Pimelea decora, P simplex (Thvmelaeaceae)... [Pg.283]

Ammi visnaga, Seseli libanotis (Apiaceae) [root]... [Pg.287]

Fern [leaf exudate], Ammi visnaga (Apiaceae), Asteraceae [leaf], Betulaceae [leaf bud exudate], Ginkgo biloba (Ginkgoaceae)... [Pg.306]

Flavone Ammi visnaga, Anethum graveolens AROM (49 68) [22] (COX,... [Pg.473]

Flavone (= 2-Phenyl-1,4- Ammi visnaga, Anethum graveolens diuretic, hypotensive cell cycle inhibition (at 20-40)] ARH-R (AD-R, COX, 5-LOX... [Pg.478]

Jouad H, Maghrani M, Eddouks M. Hypoglycemic effect of aqueous extract of Ammi visnaga in normal and streptozotocin-induced diabetic rats. J Herb Pharmacother 2002 2(4) 19-29. [Pg.328]

Khan ZA, Assiri AM, Al-Afghani HM, Maghrabi TM. Inhibition of oxalate nephrohthiasis with Ammi visnaga (Al-Khillah). Int Urol Nephrol 2001 33(4) 605-8. [Pg.328]

Ammi visnaga (toothpick weed) Angelica sinensis (dong quai) Conium maculatum (hemlock) Coriandrum sativum (coriander) Ferula assa-foetida (asafetida) Rauwolfia serpentina (snakeroot)... [Pg.1616]

Karela fruit, bitter melon Momordica charantia Toothpick weed Ammi visnaga... [Pg.1621]

Furochromones are group of coumarins, derived from y- benzopyrone. They are related to furanocoumarins and are present in plants of family Apiaeeae and Rutaceae. Ammi visnaga is a potential souree of furoehromones like khellin and visnagin. Khellin was onee used as coronary vasodilator drug. [Pg.92]

Figure 2. (A) Structures of aromatic polyketides produced by A. arborescens. (B) Khellin andvisnagin in Ammi visnaga. (C) A hypothetical scheme for the involvement of OKS and as yet unidentified ketoreductase in the biosynthesis of anthrones and anthraquinones. In the absence of interactions with the reductase, OKS Just affords SEK4/SEK4b as shunt products, (Adapted from reference 7b, Copyright 2005 American Chemical Society,)... Figure 2. (A) Structures of aromatic polyketides produced by A. arborescens. (B) Khellin andvisnagin in Ammi visnaga. (C) A hypothetical scheme for the involvement of OKS and as yet unidentified ketoreductase in the biosynthesis of anthrones and anthraquinones. In the absence of interactions with the reductase, OKS Just affords SEK4/SEK4b as shunt products, (Adapted from reference 7b, Copyright 2005 American Chemical Society,)...
See other pages where Ammi visnaga is mentioned: [Pg.1588]    [Pg.1588]    [Pg.122]    [Pg.74]    [Pg.3448]    [Pg.3448]    [Pg.285]    [Pg.287]    [Pg.327]    [Pg.327]    [Pg.159]    [Pg.111]    [Pg.45]   
See also in sourсe #XX -- [ Pg.26 ]

See also in sourсe #XX -- [ Pg.883 ]

See also in sourсe #XX -- [ Pg.883 ]

See also in sourсe #XX -- [ Pg.45 ]

See also in sourсe #XX -- [ Pg.137 ]

See also in sourсe #XX -- [ Pg.23 ]

See also in sourсe #XX -- [ Pg.289 , Pg.295 ]



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