Developmental immunotoxicology

As was the case with tier testing, developmental immunotoxicology has been driven by expert workshops to reach consensus on the most important issues three workshops were held in 2001 [79-81], and another in 2003 [82], These workshops contributed to the development of a proposed testing framework to detect developmental immunotoxicity, which is described in detail in chapter 21. 

Dietert, R.R., Developmental immunotoxicology overview of issues including critical windows of development, Reproductive Toxicology, 17,478, 2003. 

Barnett, J.B., Developmental immunotoxicology, in Experimental Immunotoxicology, Smialowicz, RJ. and Holsapple, M.R, Eds., CRC Press, Boca Raton, 1996. 

Bunn, T.L. et al., Developmental immunotoxicology assessment in the rat Age, gender and strain comparisons after exposure to Pb, Toxicol. Methods 11, 41, 2001. 

More recently, the National Institute of Environmental Health Sciences and the National Institute for Occupational Safety and Health convened a workshop in which experts in the field of developmental immunotoxicology developed a tiered approach for assaying the developmental immunotoxicity of chemicals.18 The recommended assays were separated into three groups (1) an initial set of screening assays, (2) assays for validation of a correlation between the assay end point and functional outcomes in humans, and (3) assays for research development.18 The initial screening assays included analysis of the primary antibody response to a T-dependent antigen, the delayed type... 

Prater, M.R., Blaylock, B.L., Holladay, S.D. The mouse as a model for developmental immunotoxicology, Developmental Immunotoxicology, CRC Press, Boca Raton, Florida, 2005, chap. 4. 

ILSI HESI workshop Developmental immunotoxicology and risk assessment. Washington, DC June, 2001... 

ILSI HESI roundtable discussion on developmental immunotoxicology. Washington, DC May, 2003... 

Sandler, J.D. Executive summary Developmental immunotoxicology and risk assessment. Human Exper. Toxicol., 21(9-10), 469, 2002. 

Luster, M.I., Dean, J.H. and Germolec, D.R. Consensus workshop on methods to evaluate developmental immunotoxicology. Environ, Health Perspectives, 111, 579, 2003. 

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