Apathy

Neuroleptic analgesia is so called because the combination of a major tranquilizer, a neuroleptic dmg, and a potent opiate produces an anesthetic state characterized by sedation, apathy, and mental detachment (see Psychopharmacological agents) (152). Iimovar [8067-59-2] a combination of droperidol [648-72-2], C22H22FN2O2, (19) and fentanyl (9) citrate, is used for procedures that do not require muscle relaxation. However, the onset of action is slow. 

Management apathy. Many managers capable of making decisions to begin pollution-prevention activities, do not realize the potential benefits of pollution prevention. 

Parkinson s disease (PD) patients may suffer cognitive and behavioural impairments including apathy, personality changes and visual hallucinations, with no currently recommended treatment. Their significant cholinergic deficits led to recommendation of ChEI therapeutics. 

Die neurological disorder associated with severe vitamin B12 deficiency is termed funicular myelitis. Vitamin B12 deficiency leads to disturbed choline-, phospholipid-, and nucleic-acid synthesis, resulting in spinal marrow damages. Disturbed myelin synthesis finally causes irreversible neurological failure. In addition, there are psychiatric disturbances (disturbed memory, apathy). 

Neuroleptics or antipsychotics suppress the positive symptoms of schizophrenia such as combativeness, hallucinations and formal thought disorder. Some also alleviate the negative symptoms such as affective blunting, withdrawal and seclusiveness. Neuroleptics also produce a state of apathy and emotional indifference. Most neuroleptics block dopamine D2-receptors but some, like clozapine, also block dopamine D4-receptors or serotonin 5-hydroxytryptamine2A-receptors. 

Central nervous system-euphoria, drowsiness, apathy, mental confusion, alterations in mood, reduction in body temperature, feelings of relaxation, dysphoria (depression accompanied by anxiety), nausea, and vomiting are caused by direct stimulation of the emetic chemoreceptors located in the medulla. The degree to which these occur usually depends on the drug and the dose. 

Transient mild drowsiness, sedation, nausea, depression, lethargy, apathy, confusion, constipation, diarrhea, dry mouth, incontinence, visual disturbances Transient mild drowsiness, sedation, nausea, depression, lethargy, apathy, confusion, constipation, diarrhea, dry mouth, incontinence, visual disturbances... 

Transient mild drowsiness, sedation, nausea, depression, lethargy, apathy, confusion, constipation, diarrhea, dry mouth, incontinence, visual disturbances... 

Central nervous system-headache, apathy, drowsiness, visual disturbances (blurred vision, disturbance in yellow/green vision, halo effect around dark objects), mental depression, confusion, disorientation, delirium... 

Myxedema is a severe hypothyroidism manifested by lethargy, apathy, memory impairment, emotional changes, slow speech, deep coarse voice, thick dry skin, cold intolerance, slow pulse, constipation, weight gain, and absence of menses. 

The first three characteristics are considered to be the positive symptoms of the disorder. The fourth are described as negative symptoms although they can be divided into true negative symptoms, i.e. diminished emotions and speech and reactive ones, i.e. social apathy and withdrawal brought on by the positive symptoms. Schizophrenics do not have a split personality. Normally their reaction to the positive symptoms is to withdraw quietly but occasionally they will react violently to the voices they hear and shout at them. 

At the last visit, MW s fluoxetine was changed to bupropion, pergolide was started and gradually increased to 0.25 mg three times daily, and a dandruff shampoo was started. Since that time his skin condition, attitude, apathy, stiffness, rigidity, handwriting, tremor, slowness, and kicking have improved. The UPDRs score is 5 while "on". 

Depression (apathy leading to recognition and response difficulties)... 

Amotivation Apathy, loss of effectiveness, and diminished capacity or willingness to carry out complex, long-term plans, endure frustration, concentrate for long periods, follow routines, or successfully... 

Early researchers had to contend with the disinterest and apathy of their environment. But their success awakened increasing interest. As chemistry started to show some application, it came to the attention of the powerful and the curious. The first laboratories with appointed positions in academies and universities came into... 

One of the most sensitive systems affected by lead exposure is the nervous system. Encephalopathy is characterized by symptoms such as coma, seizures, ataxia, apathy, bizarre behavior, and incoordination (CDC 1985). Children are more sensitive to neurological changes. In children, encephalopathy has been associated with PbB levels as low as 70 pg/dL (CDC 1985). The most sensitive peripheral index of neurotoxicity of lead is reported to be slowed conduction in small motor libers of the ulnar nerve in workers with 30-40 pg/dL lead in blood (Landrigan 1989). Other potential biomarkers of lead suggested for neurotoxicity in workers are neurological and behavioral tests, as well as cognitive and visual sensory function tests (Williamson and Teo 1986). However, these tests are not specific to elevated lead exposure... 

Drowsiness, apathy, and mental detachment seem to be the major effects of ololiuqui. The derivatives of lysergic acid present in ololiuqui are widely distributed throughout... 

American people had been afraid too but their fear had sunk to a warmly communicable despair that often yielded positive action and a defiant release from the thing Franklin Roosevelt called "fear itself." Now the fear which the government should be meeting with vigorous courage expressed itself in an apathy and cynicism more disturbing than bonus marchers or farmers standing on their front steps with pitchforks in their hands. 

Somnolence Lethargy, drowsiness, apathy, inability to concentrate... 

The patient experiences anxiety, apathy, bradyphrenia (slowness of thought processes), confusional state, dementia, depression, hallucinosis/psychosis (typically drug-induced), and sleep disorders (excessive daytime sleepiness, insomnia, obstructive sleep apnea, and rapid eye movement sleep behavior disorder). 

Akathisia, akinesia, and dysphoria can result in behavioral toxicity. Symptoms may include apathy and withdrawal, and patients may appear... 

Another assumption that we professionals sometimes make is that we should be able to help our clients get better, when the reality is that they must help themselves. We can show them the door, but ultimately it is the clients who must walk through it to better health. When a person does not walk through the door, it is easy to personalize our responsibility for the lack of progress and get frustrated because we could not help him or her. Long-term frustration in working with clients can lead to apathy or disillusionment, stepping stones toward what some have called professional burnout. In my opinion, burnout occurs as a result of unrealistic expectations by professionals about their own abilities to help others and of unrealistic expectations for their clients to get better. The truth is that behavior change is completely up to the client. We can motivate and teach but we cannot force people to act. 

Apathy or Indiffernce Sluggish, don t care, passive, not alert. Such attitude has a detrimental affect on co-workers in that it can infect the entire organization. 

SYSTEMIC EFFECTS Occurs primarily through inhalation and ingestion. The T vapor or aerosol is less toxic to the skin or eyes than the liquid form. When inhaled, the upper respiratory tract (nose, throat, tracheae) is inflamed after a few hours latency period, accompanied by sneezing, coughing and bronchitis, loss of appetite, diarrhea, fever, and apathy. Exposure to nearly lethal doses of T can produce injury to bone marrow, lymph nodes, and spleen as indicated by a drop in white blood cell (WBC) count and, therefore, results in increased susceptibility to local and systemic infections. Ingestion of T will produce severe stomach pains, vomiting, and bloody stools after a 15-20 minute latency period. 

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