Behavioral toxicity

Dorfmueller MA, Henne SP, York RG, et al. 1979. Evaluation of teratogenicity and behavioral toxicity with inhalation exposure of maternal rats to trichloroethylene. Toxicology 14 153-166. 

The stimulation of locomotor activity by MDMA and the importance of mesolimbic dopamine in this response reflect similarities with the prototype phenylethylamine stimulant, amphetamine. It is important to note that these parameters are frequently associated with rewarding aspects of drugs and drug abuse. Additionally, the behavioral profiles of MDMA and I E share certain characteristics with hallucinogen-Iike agents. This unique mixture of stimulus properties and neurochemical actions may contribute to a dangerous behavioral toxicity and neurotoxic potential for drugs like MDMA. 

University of Rochester, Behavioral toxicity of lead role of the Rochester, NY NMDA receptor... 

Cory-Slechta DA. 1997b. Relationships between Pb-induced changes in neurotransmitter system function and behavioral toxicity. Neurotoxicology 18(3) 673-688. 

Cory-Slechta DA, Thompson T. 1979. Behavioral toxicity of chronic postweaning lead exposure in the rat. Toxicol Appl Pharmacol 47 151-159. 

Cory-Slechta DA, Weiss B, Cox C. 1983. Delayed behavioral toxicity of lead with increasing exposure concentrations. Toxicol Appl Pharmacol 71 342-352. 

Gilbert SG, Rice DC. 1987. Low-level lifetime lead exposure produces behavioral toxicity (spatial discrimination reversal) in adult monkeys. Toxicol Appl Pharmacol 91 484-490. 

Rice DC. 1985a. Behavioral toxicity in monkeys exposed to low levels of lead from birth. 

Rice DC, Gilbert SG. 1985. Low-level lead exposure from birth produces behavioral toxicity (DRL) in monkeys. Toxicol Appl Pharmacol 80 421-426. 

Reiter, L.W. and P.H. Ruppert. 1984. Behavioral toxicity of trialkyltin compounds a review. Neurotoxicology 5 177-186. 

Hall, A.T. 1993. Reproductive and Behavioral Toxicity of Anthracene in the Fathead Minnow (Pimephales promelas). Ph.D. thesis. Miami Univ., Oxford, OH.151 pp. 

Akathisia, akinesia, and dysphoria can result in behavioral toxicity. Symptoms may include apathy and withdrawal, and patients may appear... 

Use in general toxicity testing and reproduction, teratological and behavioral toxicity (aspects of public acceptance as a species for testing)... 

Balster RL, Borzelleca JF. 1982. Behavioral toxicity of trihalomethane contaminants of drinking water in mice. Environ Health Perspect 46 127-136. 

RufRn, J. B. Functional testing for behavioral toxicity A missing dimension in experimental environmental toxicology. J. Occup. Med. 5 117-121, 1%3. 

The behavioral toxicity that can accompany SNA intoxication can lead to head and other Injuries and perhaps leave permanent residua. Such injury would occur during intoxication or delrlum and would have been recorded In the Edgewood subjects charts. No such incidents were recorded. 

Patients can develop behavioral toxicity, which in its severe form may be characterized by disorientation, loss of immediate memory, and florid hallucinations. 

The most common MAOl behavioral toxicity is the precipitation of a hypomanic or manic episode, but restlessness, hyperactivity, agitation, irritability, and confusion can also occur. Rare cases of paranoid psychosis have been reported. 

The term behavioral toxicity has been used in the child psychiatry literature to describe the following adverse effects of antipsychotics, particularly low-potency phenothiazines (e.g., chlorpromazine, thioridazine) ... 

Although severe disruption in the sleep-wake cycle is a common feature of dementia, the use of BZDs in such cases may also produce significant behavioral toxicity. Alternative drug approaches include bedtime use of olanzapine in nondepressed patients or trazodone in depressed patients. 

Bomschein, R.L., Hastings, L. Manson, J.M. (1980) Behavioral toxicity in the offspring of rats following maternal exposure to dichloromethane. Toxicol, appl. Pharmacol., 52, 29-37... 

Verster JC, Volkerts ER. Clinical pharmacology, clinical efficacy, and behavioral toxicity of alprazolam a review of the literature. CNS Drug Rev. 2004 10 45-76. 

Weiss, B., and D. Cory-Slechta. Assessment of behavioral toxicity. In Principles and Methods of Toxicology, 3rd ed. A. Wallace Hayes, ed. New York Raven Press, 1994. 

In another drinking water study, both single and repeated doses of triethyltin bromide produced performance decrements in a series of behavioral toxicity tests in rats (Reiter et al. 1980). The effects were rapid in onset but reversible 1 month after exposure was discontinued. Such findings correlate well with the effects on the myelin sheath (i.e., demyelination). These changes also illustrate the characteristic effects of the triethyltins as compared to trimethyltins. The authors estimated that a behavioral threshold for the rat is between 8-10 mg/kg/day triethyltin bromide for a 3-week exposure. 

Reiter L, Kidd K, Heavner G, et al. 1980. Behavioral toxicity of acute and subacute exposure to triethyltin in the rat. Neurotoxicology 2 97-112. 

Bornschein, R.L.. L. Hastings and J.M. Hanson, "Behavioral Toxicity of the Offspring of Rats Exposed to Dichloromethane (DCM) Prior to and/or During Gestation," Toxicol. Appl. Pharmacol. 52, 29-37 (1980). 

Yokel RA. 1989. Aluminum produces age related behavioral toxicity in the rabbit. Neurotoxicol Teratol 11 237-242. 

Gerhardt, A., Schmidt, S. and Hoss, S. (2002b) Measurement of movement patterns of Caenorhabditis elegans (Nematoda) with the Multispecies Freshwater Biomonitor (MFB) - a potential new method to study a behavioral toxicity parameter of nematodes in sediments, Environmental Pollution 120 (3), 513-516. 

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