Antihistamines analysis

Fernandez G, Gomez M D, Castro J 1975 Cholinesterase inhibition by phenothiazine and nonphenothiazine antihistaminics analysis of its postulated role in synergizing organophosphate toxicity. Toxicology and Applied Pharmacology 31 179-190... 

Another potential benefit of UHPLC is its capability of solving the most challenging separation tasks in pharmaceutical analysis. Figure 9.4 shows a UPLC method developed to analyze pharmaceutical formulations used to treat the common cold. Cold products often contain multiple active ingredients to treat different symptoms and can contain decongestants, antihistamines, pain relievers, cough suppressants, expectorants, and numerous excipients of various polarities. The analysis of a total of 20 components was achieved within 10 min. 

The findings of the intensive QSAR analysis conducted by Rekker et al. [10] led to the conclusion that antihistaminic activity may be expected in compounds characterized by the presence of a hydrophobic group (the diaryl moiety) at a certain distance (the linker) from a positive charge (the basic function). The hydrophobic moiety is by far the most critical part for antihistaminic activity. In fact, the often-used term hydrophobic pocket is rather misleading, as the part of the receptor to... 

Antihistamines are not first-choice drugs in asthma, however, and although they can contribute to the relief of seasonal asthma symptoms and accompanying allergic rhinitis, the results of a meta-analysis do not support the general use of antihistamines in adult asthmatics (40). 

Hey JA, del Prado M, Sherwood J, Kreutner W, Egan RW. Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects. Arzneimittelforschung 1996 46(2) 153-8. 

Van Ganse E, Kaufman L, Derde MP, Yernault JC, Delaunois L, Vincken W. Effects of antihistamines in adult asthma a meta-analysis of clinical trials. Eur Respir J 1997 10(10) 2216-24. 

Didier A, Doussau-Thuron S, Murris-Espin M. Comparative analysis of the sedative effects of mequita-zine and other antihistaminic drugs review of the literature. Curr Ther Res Clin Exp 2000 61 770-80. 

Seto A, Einarson T, Koren G. Pregnancy outcome following first trimester exposure to antihistamines meta-analysis. Am J Perinatol 1997 14(3) 119-24. 

In a retrospective chart analysis in a Greek ENT department 42 patients with allergic reactions to E. elaterium, including upper airway edema, were identified (7). Treatment with glucocorticoids and antihistamines resulted in full recovery in all cases. 

Numerous methods have been published for analysis of tricyclic antidepressants. These drugs present various problems to the clinical laboratory (1) the therapeutic serum concentration is 10 to 100 times lower than that of other commonly monitored drugs, and thus to be clinically useful, the method must be able, to measure serum concentrations <50ng/mL (2) these drugs have metabolites that must also be measured and (3) these drugs are structurally similar to common sleep inducers, antihistamines, and many over-the-counter medications used for appetite suppression, which are potential interferences. Of the many hundreds of methods published, only a few have satisfactorily overcome these obstacles. 

No,Dmethphan,caf Antitussives, Analysis anticold drugs expectorants, antihistaminics... 

Antagonists - Recent structure-activity studies of Hj -receptor antihistamines have been concerned with stereochemical aspects, partition characteristics, pattern recognition, affinity contributions to activity and association phenomena. The subject has also been reviewed recently. Undoubtedly, the main focus of attention has been on the H2 receptor histamine antagonists. Three compounds have been widely studied, viz. burimamide (13b), metiamide (13c) and cimetidine (13d), and their pharmacological properties summarized. 3 Their discovery and development at SK F was the culmination of a research programme initiated in 1964. The search for an antagonist and some of the medicinal chemical approaches used in the structure-activity analysis have been outlined in several articles. Concurrently, other researchers had sought... 

Liao E, Leahy M, Cummins G The costs of nonsedating antihistamine therapy for allergic rhinitis in managed care An updated analysis. Am J Manag Care 2001 7 S459-S468. (Ill)... 

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