Antihistamine drugs analysis

Didier A, Doussau-Thuron S, Murris-Espin M. Comparative analysis of the sedative effects of mequita-zine and other antihistaminic drugs review of the literature. Curr Ther Res Clin Exp 2000 61 770-80. 

Other literature presented a rapid method for the determination of Dioxopro-methazine hydrochloride (DPZ) (an antihistamine drug) by CE-ECL using Ru(bpy)3 reagent. The proposed method was of high sensitivity, good selectivity, and reproducibility for DPZ analysis. This CE-ECL method was applied to analyze DPZ in real samples including tablets, rat serum, and human urine [45]. 

The Analysis of Antihistamine Drugs by Gas Chromatography-Mass Spectrometry... 

Antihistamines are not first-choice drugs in asthma, however, and although they can contribute to the relief of seasonal asthma symptoms and accompanying allergic rhinitis, the results of a meta-analysis do not support the general use of antihistamines in adult asthmatics (40). 

Numerous methods have been published for analysis of tricyclic antidepressants. These drugs present various problems to the clinical laboratory (1) the therapeutic serum concentration is 10 to 100 times lower than that of other commonly monitored drugs, and thus to be clinically useful, the method must be able, to measure serum concentrations <50ng/mL (2) these drugs have metabolites that must also be measured and (3) these drugs are structurally similar to common sleep inducers, antihistamines, and many over-the-counter medications used for appetite suppression, which are potential interferences. Of the many hundreds of methods published, only a few have satisfactorily overcome these obstacles. 

No,Dmethphan,caf Antitussives, Analysis anticold drugs expectorants, antihistaminics... 

In January 2008, Australian actor Heath Ledger was found dead, and toxicology analysis revealed the presence of prescription medication. Oxycodone and hydrocodone (opioid analgesics) diazepam, temazepam, and alprazolam (benzodiazepines) and doxylamine (antihistamine) were all found in the samples from the deceased. The coroner in the case concluded that death was due to the combined effects of these drugs. As mentioned, GC-MS has been the gold standard for these types of analyses however, LC-MS/MS in particular is being reported in the scientific literature. 

Examples of applications of this analysis include the dissociations ol aminobenzoic acids [437], arginine [438], the anti-inflammatory drug niflumic acid [439], and the antihistamine cetirizine [440]. 

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