Selective serotonin and

Spealman R. Modification of behavioral effect of cocaine by selective serotonin and dopamine uptake inhibitors in squirrel monkeys. Psychopharmacology. 112 93, 1993. 

Selective serotonin and noradrenaline reuptake inhibitors (SNRIs)... 

DUAL SELECTIVE SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS (SSNRIs)... 

Side effects, mainly due to serotonin reuptake inhibition include G1 upset, nervousness, and sexual dysfunction. SSRls are associated with an increased risk of falls. Hyponatraemia due to SIADH is an uncommon, but important side effect in elderly patients. Selective serotonin and norepinephrine reuptake inhibitors (S SNRls) such as venlafaxine and duloxetine are also useful in older patients. Other heterocyclic antidepressants of importance in older patients because of relative safety include bupro-prion and mirtazepine. They are reserved for patients with resistance to or intolerance of SSRls. Currently, trazodone is used mostly for sleep disturbance in depression in doses of 50-100 mg at bedtime. The monoamine oxidase inhibitors phenelzine. 

Post-2000 Renal rhabdomyolysis with the statin, cerivastin cardio-toxicity with the COX-2 inhibitor, rofecoxib and liver damage with the selective serotonin and norepinephrine reuptake inhibitor, atomoxetine. 

Venlafaxine is one of the first selective serotonin and norepinephrine reuptake inhibitors developed for the treatment of depression. It was originally released in the United States in 1994. 

Traditionally, benzodiazepines and tricyclic antidepressants (TCAs) have been the most prescribed drug treatments for GAD. However, selective serotonin reuptake inhibitors (SSRIs), as well as selective serotonin and norepinephrine... 

Harmer, C.J., Shelley, N.C., Cowen, P.J., and Goodwin, G.M. (2004). Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. American Journal of Psychiatry, 161, 1256-1263. 

NSAID, Nonsteroid anti-inflammatory drug SNRI, Selective serotonin and nonadrenaline reuptake inhibitor SSRI, Selective serotonin reuptake inhibitor... 

Thiophene seems to be very popular in Li Lilly drugs. Its dual selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for depression, duloxetine (Cymbalta), contains a thiophene. And its atypical antipsychotic drug olanzapine (Zyprexa) has a fused thiophene as its core structure. 

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). Duloxetine is available as delayed-release capsules for oral route. 

Asymmetric synthesis is also common. Another technique is kinetic resolution. Kinetic resolution relies upon a difference in reactivity between the two enantiomers. For example this technique can be used in the synthesis of duloxetine. Duloxetine is marketed as the hydrochloride salt under the tradename Cymbalta as an antidepressant. It is a selective serotonin and norepinephrine reuptake inhibitor. It is the S enantiomer which is used. 

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