Anticonvulsant analgesics

Acorns calamus L. var. angustatus Besser A. gramineus Ait. A. tatarinowii L. Chang Pu (Sweet flag) (leaf, root) Acoric acid, beta-asarone, yellow bitter aromatic volatile oil, alpha-pinene, d-camphene, calamene, calamenol, calamenone.50,357-450 Anticonvulsant, analgesic, aphrodisiac, carminative, contraceptive, dessicant, diaphoretic. 

Acorns calamus L. A. gramineus Ait. China Acoric acid.50 Anticonvulsant, analgesic, aphrodisiac, carminative, contraceptive, dessicant, diaphoretic. 

Gabapentin Neurotin Aclonium Anticonvulsant/ analgesic CNS depressant mp 164 °C Treatment of neuralgia, pain from shingles, migraine, and epilepsy H2N COOH c5... 

Class anticonvulsant analgesic Chemical Structure see Figure 71.1... 

The CCK system shares one property with the opioid system, ie, the existence of selective nonpeptide antagonists. These include aspedicine, a natural benzodiazepine (136), and Devazepide (L-364,718 MK-329) (137). Selective, potent peptide antagonists for CCK, eg, Cl-988 and PD 134308, have been developed that maybe useful as anxiolytics and as dmgs which increase the analgesic effect of morphine but at the same time prevent morphine tolerance (138) (see Hypnotics, sedatives, anticonvulsants, and anxiolytics). 

See Alkaloids Analgesics, antipyretics, and antiinflammatory agents Hypnotics, sedatives, anticonvulsants, and anxiolytics. 

Many 1,2,3,5-benzenetetrol derivatives are used mediciaaHy. For example, khellin [82-02-0] (65), which is a naturally occurring benzopyranone, is used as a coronary vasodilator and bronchodilator (233). Derivatives of khellin are effective local anesthetics and antiarrythmics (234). Similarly, amine derivatives (68) that are prepared from khellinone oxime (66) exhibit hypnotic, sedative, anticonvulsant, antiinflammatory, cardiac analeptic, diuretic, and antiulcerous activity (235) (see Analgesics, antipyretics, and antiinflammatory agents). 

Ethoheptazine as analgesic, 1, 167 Ethosuximide as anticonvulsant, 1, 166 Ethoxzolamide as diuretic, 1, 173 Ethylamine, o-bromophenyl-indole synthesis from, 4, 322 Ethylamine, 2-thienyl-biological activity, 4, 911 Ethylamine, 3-thienyl-biological activity, 4, 912 Ethylene... 

Therapeutic Function Analgesic, Anticonvulsant Chemical Name 5H-dibenz[b,f] azepine-5-carboxamide Common Name 5-carbamyl iminostilbene Structural Formula ... 

Pregnancy Category C drug and is used with caution during pregnancy. As with all anticonvulsants, when the succinimides are used with other CNS depressants (eg, alcohol, narcotic analgesics, and antidepressants), an additive CNS depressant effect may occur. 

Additional in vivo studies on the biological activity of proanthocyani-dins investigating a series of behavioral activities (motihty, body weight gain, body temperature, motoric coordination, anticonvulsant effects and central analgesic activities) showed no or only moderate pharmacological effects [53]. On the other hand, dietary supplementation with cocoa pro-cyanidin supplements can dose-dependently prevent the development of hyperglycemia in diabetic obese mice [54]. 

Drugs Available No specific anti-viral drugs are available, but supportive therapy might call for analgesics and anticonvulsants. 

Medical Management No specific viral therapy exists so treatment is supportive only. Treat patients with uncomplicated VEE infection with analgesics to relieve headache and myalgia. Patients who develop encephalitis could require anticonvulsants and intensive care to maintain fluid and electrolyte balance, ensure adequate ventilation, and avoid complicating secondary bacterial infections. Patients should be treated in a screened room or in quarters treated with residual insecticide for at least five days after onset, or until afebrile (without fever) to foil mosquitoes since humans may remain infectious for mosquitoes for at least seventy-two hours. Isolation and qaurantine is not required. Standard Precautions should be practiced when dealing with infection control for VEE victims as shown below ... 

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