Body weight gain

Food nd W ter Consumption. Measurement of changes in food and water consumption may indicate a toxic potential, and can give guidance on the reason for abnormal body weight gains. 

A study on Wistar rats by Farr et al. (2001) showed no maternal toxicity at doses up to 5 mg/kg body weight for dibutyltin dichloride signs of maternal toxicity — reduced body weight gain, decreased food consumption, and thymus weight — were observed at 10 mg/kg body weight. No teratogenic effects were seen at 10 mg/kg... 

Dibutyltin Rat DBTC Gestation days 7-15at0, 2.5, 5, 7.5, and 10 mg/kg body weight Maternal toxicity body weight gain Teratogenicity LOAEL = 7.5 NOAEL = 5 LOAEL = 5 NOAEL = 2.5 Ema et al. (1991)... 

M (emaciation, dehydration in 2 of 8 dogs 30% reduced body weight gain)... 

No effects on female fertility were noted in rats treated by gavage with trichloroethylene in com oil at 1,000 mg/kg/day for 2 weeks before mating through gestation and postnatal days 0-31 (Manson et al. 1984). Maternal body weight gain was about 9% lower than controls at 1,000 mg/kg/day. 

Additional in vivo studies on the biological activity of proanthocyani-dins investigating a series of behavioral activities (motihty, body weight gain, body temperature, motoric coordination, anticonvulsant effects and central analgesic activities) showed no or only moderate pharmacological effects [53]. On the other hand, dietary supplementation with cocoa pro-cyanidin supplements can dose-dependently prevent the development of hyperglycemia in diabetic obese mice [54]. 

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