Opioid Systems

The CCK system shares one property with the opioid system, ie, the existence of selective nonpeptide antagonists. These include aspedicine, a natural benzodiazepine (136), and Devazepide (L-364,718 MK-329) (137). Selective, potent peptide antagonists for CCK, eg, Cl-988 and PD 134308, have been developed that maybe useful as anxiolytics and as dmgs which increase the analgesic effect of morphine but at the same time prevent morphine tolerance (138) (see Hypnotics, sedatives, anticonvulsants, and anxiolytics). [Pg.204]

In addition to the weU-defined opioid systems in the central nervous system, the three opioid peptides and their precursor mRNA have also been identified in peripheral tissues. ( -Endorphin is most abundant in the pituitary, where it exists in corticotroph cells with ACTH in the anterior lobe and in melanotroph cells with MSH in the intermediate lobe (59). Enkephalin and pre-pro-enkephalin mRNA have been identified in the adrenal medulla (60) and this has been the source of material for many studies of pro-enkephalin synthesis and regulation. Pre-pro-enkephalin mRNA has also been identified in the anterior and posterior lobes of the pituitary (61). mRNA for all three opioid precursors has been identified in the reproductive system (62—64). POMC... [Pg.446]

Non-steroidal Anti-inflammatory Drugs Opioid Systems Local Anaesthetics Voltage-dependent Na+ Channels... [Pg.79]

Opioids ( opioid systems) are thought to exert their antitussive effects by acting as agonists at p- and K-opioid receptors in the CNS. Activation of these receptors activates various G-proteins and leads to the inhibition of... [Pg.194]

Opioid systems in the brain are important for the reinforcing effects of ethanol. Selective p-opioid receptor antagonists reliably decrease ethanol drinking in rats. [Pg.485]

Opioid Systems. Table 1 Opioid receptors and ligands... [Pg.904]

Opioid Systems. Table 2 Endogenous opioid peptides... [Pg.904]

Opioid Systems. Table 3 Cellular responses to opioids... [Pg.905]

Kieffer BL, Gaveriaux-Ruff C (2002) Exploring the opioid system by gene kockout. Progr Neurobiol 66 285-306... [Pg.907]

Mayer P, Hollt V Allelic and somatic variations in the endogenous opioid system of humans. Pharmacol Ther 91 167-177, 2001... [Pg.104]

Braida D, Pozzi M, Cavallini R, et al Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat interaction with the opioid system. EurJ Pharmacol 413 227-234, 2001... [Pg.176]

Knapp PE, Maderspach K, Hauser KF (1998) Endogenous opioid system in developing normal and jimpy oligodendrocytes p, and k opioid receptors mediate differential mitogenic and growth responses. Glia 22 189-201... [Pg.371]

As one might expect, similar interactions between chemokine and opioid systems have been observed in the central nervous system as weU. In 2002, Szabo et al. [Pg.386]

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