Anticancer Agents and Immunosuppressants

Supportive care, administration of antiemetics, corticosteroids, and nutritional supplements may be used to treat the adverse effects of anticancer drugs. Scalp 

Calcium channel blockers and prostaglandins have been used to reduce the nephrotoxic effects of cyclosporin during kidney transplantation.201 Interleukin-2 should be taken cautiously when coadministered with NSAIDs.202 Coadministration of tamoxifen with allopurinol and anticoagulants should be monitored carefully.203 

Amsacrine Amsacrine is incompatible with sodium chloride mixtures and glucose-containing injections with acyclovir sodium, ganciclovir sodium, aztreonam, amphotericin, cimetidine hydrochloride, ceftazidime, frusemide, ceftriaxone sodium, heparin sodium, methylprednisolone sodium succinate, metoclopramide hydrochloride, and some antineoplastics.204 Asparaginase is incompatible with many drugs and rubber, and should be stored at 2° to 8 °C for stability. 

Bleomycin Bleomycin is incompatible and loses its potency if it is administered with solutions of benzylpenicillin sodium, carbenicillin, cephazolin or cephalothin sodium, hydrocortisone sodium succinate, mitomycin, methotrexate, nafcillin sodium, aminophylline, ascorbic acid, terbutaline, divalent and trivalent cations (especially copper), compounds containing sulfhydryl groups, and precipitation by hydrophobic anions, essential amino acids, riboflavine, dexamethasone, and frusemide. 

Bleomycin sulfate should not be diluted in 5% glucose-infusion solutions. Loss of activity of bleomycin was reported with different packaging materials.205 Patients under treatment with bleomycin must avoid driving 206 

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Cyclophosphamide is an alkylating agent employed as an anticancer agent and immunosuppressant to prevent the rejection of organ transplants (Figure 34.4). In humans, exposure to cyclophosphamide during the first trimester is associated with... 

NSC 368390) is a quinolinecarboxylic acid derivative, which inhibits de novo pyrimidine biosynthesis and acts as an ANTICANCER AGENT and IMMUNOSUPPRESSANT that has been used in organ transplantation, brequinar sodium brequinar. 

Didemnin B (347) is a cyclic depsipeptide isolated from the Caribbean tunicate Trididemnum solidum and is currently in phase II clinical trials as an anticancer agent. Didemnin B also shows antiviral and immunosuppressive activity. The structure of didemnin B was revised to 347 containing... 

Cyclophosphamide is used in human medicine as an antineoplastic (anticancer) agent in a variety of applications. Cyclophosphamide is a potent immunosuppressive agent and is used to prevent rejection episodes following renal, hepatic, and cardiac transplantation and in non-neoplastic disorders in which... 

NSC 109724 Asta 4942 Ifex Mitoxana and many other names) is related to cyclophosphamide, and also is an (alkylating) cytotoxic ANTICANCER and immunosuppressant AGENT. It works by interfering with cellular DNA and so inhibits cell replication. It is particularly used for testicular cancer, and is routinely used simultaneously with mesna (which reduces the urothelial toxicity), i-inositol myo-inositol. 

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