Immunosuppressants Immunosuppressive agents

ANIMAL EXPERIMENTS ANTIBODY FORMATION/DRUG EFF CYCLOPHOSPHAMIDE/THER USE ENGLISH ABSTRACT HYPERSENSITIVITY HYPERSENSITIVITY DELAYE/DRUG THY IMMUNIZATION IMMUNOSUPPRESSION IMMUNOSUPPRESSIVE AGENTS/THER USE MALE RATS SKIN TESTS TOXlNS/PHARMACO... [Pg.8]

Immunosuppression induced by sirolimus (36) appears to be mediated by a mechanism distincdy different from that of either cyclosporin or FK-506. Sirolimus markedly suppresses IL-2 or IL-4-driven T-ceU proliferation. The preclinical studies suggest that sirolimus is a potent immunosuppressive agent in transplantation and autoimmune disease models. The clinical potential of this agent depends on its toxicity profile (80). [Pg.42]

FK-506 (37) interferes with IL-2 synthesis and release and has a cyclosporin-like profile, but is considerably more potent in vitro. IC q values are approximately 100-fold lower. This neutral macroHde suppresses the mixed lymphocyte reaction T-ceU proliferation generation of cytotoxic T-ceUs production of T-ceU derived soluble mediators, such as IL-2, IL-3, and y-IFN and IL-2 receptor expression (83). StmcturaHy, FK-506 is similar to sirolimus. Mycophenolate mofetil (33), brequinar (34), and deoxyspergualin are in various phases of clinical evaluation. Identification of therapeutic efficacy and safety are important factors in the deterrnination of their utiUty as immunosuppressive agents. [Pg.42]

MTX is part of curative therapeutic schedules for acute lymphoblastic leukemias (ALL), Burkitt s lymphoma, and choriocarcinoma. It was also used in adjuvant therapy of breast cancer. High dose MTX with leucovorin rescue can induce about 30% remissions in patients with metastatic osteogenic sarcoma. MTX is one of the few antineoplastic drugs that can be safely administered intrathecally for the treatment of meningeal metastases and leukemic infiltrations (routine prophylaxis in ALL). In addition, MTX can be used as an immunosuppressive agent for the treatment of severe rheumatoid arthritis and psoriasis. [Pg.148]

Amongst the —> immunosuppressive agents besides the —> glucocorticoids the modern nontoxic drugs have become drugs of choice including ciclosporin, tacrolimus or ascomycin. [Pg.242]

Immunosuppressive Agents Protein Phosphatases Ryanodine Receptor... [Pg.507]

Gluco-mineralocorticoid Receptors Immunosuppressive Agents Inflammation... [Pg.543]

Glucocorticoids Immunosuppressive Agents Bronchial Asthma Allergy... [Pg.543]

Immunosuppressive agents (immunosuppressants) are drugs that attenuate immune reactions. An application is indicated in case our immune system reacts inadequately leading to serious diseases or normal immune reactions are unwanted, e.g., following transplantations. [Pg.618]

Glucocorticoids belong to the oldest immunosuppressive agents given to transplant recipients and are... [Pg.621]

Immunosuppressive agents are indicated for the therapy of systemic autoimmune diseases (e.g., systemic lupus... [Pg.621]

In the pathogenesis of many chronic inflammatory diseases (e.g., rheumatoid arthritis, glomerulonephritis, colitis ulcerosa, Morbus Crohn, atopic dermatitis, psoriasis) autoimmune processes play an important role, too. Although first of all nonsteroidal antiinflammatory agents or glucocorticoids should be applied, immunosuppressive agents may also be indicated. [Pg.622]

Kiani A, Rao A, Arambura J (2000) Manipulating immune responses with immunosuppressive agents that target NFAT. Immunity 12 359-372... [Pg.850]

Activities of 748 (FIAC), 758 (FMAU), and related compounds against several viruses were compared, " and the combined effects of 748 (FIAC) and 758 (FMAU) with other antiviral drugs, or with cyclophosphamide (for FMAU), an immunosuppressive agent, were examined. [Pg.249]

Nerenberg, I.B., Hung, D.T., Somers, P.K., Scheiber, S.L. (1993) Total Synthesis ofthe Immunosuppressive Agent (—)-Discodermolide. Journal of the American Chemical Society, 115, 12621-12622. [Pg.192]

Gram-negative coverage is indicated for patients with diabetes, HIV infection, prosthetic valves, or those receiving immunosuppressive agents (gentamicin 2 mg/kg intravenously with serum concentration monitoring). [Pg.397]

Compare and contrast the currently available immunosuppressive agents in terms of mechanisms of action, adverse events, and drug-drug interactions. [Pg.829]

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