Quinolinecarboxylic acids

Eu(III) complexes of quinolinecarboxylic acids, including 5, were studied (00MI31). Those of complexes of 5 with Eu(III) and Tb(III) ion were studied, and they were applied for analysis of 5 in medicinal preparations (00UKZ115). Stability of lanthanide complexes with 5 was studied (00MI67). The fluorescence spectra of 5 complexed with Co(II) and ATP was measured (01SA(A)1317). 

CN l-cyclopropyl-6-fluoro-l,4-dihydro-4-oxo-7-(l-piperazinyl)-3-quinolinecarboxylic acid... 

CN ( )-l-ethyl-6,8-difluoro-l,4-dihydro-7-(3-methyl-l-piperazinyl)-4-oxo-3-quinolinecarboxylic acid monohydrochloride... 

C kH,xO 3247-97-2) sec Amitriptyline l-cycIopropyl-6-fluoro-l,4-dihydro-5-mcthyl-7-(3-methyK l-piperazinyl)-4-oxo-3 quinolinecarboxylic acid ethyl ester... 

When the cyclization of compound 807 (R = H) was carried out in boiling phosphoryl chloride, the isomeric chloro derivatives (816 and 817) were obtained in 98% yield. They were separated by the use of column chromatography, in which the linear product (816) was prepared in 50% yield, and the angular product (817) was prepared in 27% yield (74GEP2335760). Earlier, 31% offuro[2,3-j ]quinolinecarboxylic acid (814, R = H) and 7% of furo[3,2-/]quinolinecarboxylic acid (815, R = R1 = H) were isolated from the cyclization of compound 807 (R = H) in phosphoryl chloride and after hydrolysis of the reaction product with hydrochloric acid (71GEP2030899). 

The cyclization of isopropylidene 1-indolinylmethylenemalonates (1202) was carried out in polyphosphoric acid at 100°C to yield pyrrolo[3,2,l-y]quinoline-2-carboxylic acids (1203) [82BEP891046, 82BEP891537 83JAP(K)90511], Further pyrrolo[3,2,l-(/]quinolinecarboxylic acids were prepared similarly, in 82-86% yields [82BEP891046, 82BEP891537, 82JAP(K)2285]. 

Quinolinecarboxylic acids 235 and 236 are also deprotonated with LiTMP (Scheme 114) 43 ... 

Aminopiperidinyl]-l-cyclopropyl-l,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid. 

Synthetic auxins Phenoxyalkanoic acids Benzoic acids Pyridinecarboxylic acids Quinolinecarboxylic acids 4... 

The selective carbonylation of 4,7-dichloroquinoline proceeds readily and the chlorine in the more active 4-position reacts preferentially to give quinolinecarboxylic acid derivatives in excellent yield (7.65.), The carbon-chlorine bond in the 7-position is so unreactive that attempts at the preparation of dicarboxylic acid derivatives were only moderately successful.86... 

Fluorine is used for the fluorination of sites x to sulfoxides with simultaneous oxidation of the sulfoxide moiety to a sulfone. The electrophilic fluorine attacks the electron lone pairs of the sulfur atom with a consequent loss of hydrogen fluoride forming an S-fluorosulfoxy alkene. A second molecule of fluorine adds across the newly formed double bond resulting, after hydrolysis, in an a-fluoro sulfone 12.88 This reaction is used for the construction of a fluorocy-clopropane derivative 13 which is essential in the synthesis of one of the most promising members of the quinolinecarboxylic acid antibiotics.89... 

D is found in compounds like quinolyl esters of N-substituted dithio-carbamic acids. A wide variety of compounds containing the quinoline system are herbicides. Derivatives and salts of 8-quinolinecarboxylic acid as well as quinolyl carbamates are each useful insecticides. The copper salt of 8-hydroxyquinoline is an effective fungicide. 

Quinolinecarboxylic acid, AQ73 Quinoline N-oxide, AO83 Quinoline N -oxide, A084... 

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