Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Bleomycin sulfate

Bleomycin sulfate is used alone or in combination with other antineoplastic dmgs. Using this DNA-cleaving dmg, disease-free (possibly cured) survivors of some cancers have been seen, especially with the use of bleomycin in multidmg regimens. General reviews of bleomycin (234,242—245) and its mechanism of action (246—249) are available. [Pg.158]

Bleomycin sulfate USP, a white or yellowish powder, is very soluble in water and sparingly soluble in alcohol. It is 55—70% bleomycin A2 and 25—32% bleomycin based on total bleomycin base content as deterruined by hplc. This combination was found to be more effective than use of either bleomycin alone (234). [Pg.158]

A patient weighing 120 pounds is to receive bleomycin sulfate (Blenoxane) 0.25 units per kilogram of body weight. What is the correct dosage of bleomycin ... [Pg.602]

Various cytotoxic antibiotics bleomycin sulfate mitomycin mitotane... [Pg.620]

Bleomycin sulfate should not be diluted in 5% glucose-infusion solutions. Loss of activity of bleomycin was reported with different packaging materials.205 Patients under treatment with bleomycin must avoid driving 206... [Pg.360]

Blcnoxanc.. Vtr Bleomycin sulfate Bleomycin sulfate. 417-419. 423 Blocadrcn. See Tiinulol /3-BIockcr. 541-546... [Pg.962]

BLEOMYCIN SULFATE (Blenoxane sterile powder for injection)... [Pg.109]

One family of antitumorigenic compounds used in practice are the bleomycins, natural products that contain iron isolated from Streptomyces cultures. Bleomycin sulfate is used in combination chemotherapy for treatment of head and neck cancer. The mechanism of action of bleomycin is believed to include the binding of oxygen to form 02-Fe(II)-BLM. This complex can accept an electron to produce an active species, 02 -Fe(III)-BLM, which can cleave DNA and RNA, ultimately killing the cancer cell. [Pg.48]

See other pages where Bleomycin sulfate is mentioned: [Pg.119]    [Pg.119]    [Pg.157]    [Pg.160]    [Pg.439]    [Pg.584]    [Pg.38]    [Pg.92]    [Pg.639]    [Pg.647]    [Pg.37]    [Pg.92]    [Pg.119]    [Pg.119]    [Pg.357]    [Pg.423]    [Pg.278]    [Pg.52]    [Pg.157]    [Pg.160]    [Pg.287]    [Pg.109]    [Pg.109]    [Pg.520]    [Pg.37]    [Pg.92]    [Pg.1807]    [Pg.22]    [Pg.37]   
See also in sourсe #XX -- [ Pg.92 ]

See also in sourсe #XX -- [ Pg.92 ]

See also in sourсe #XX -- [ Pg.109 ]

See also in sourсe #XX -- [ Pg.92 ]



SEARCH



Bleomycin

Bleomycinic acid Peplomycin sulfate

© 2024 chempedia.info