Amyloid beta Fibrils

Goldsbury, C., Frey, P., Olivieri, V., Aebi, U., and Muller, S. A. (2005). Multiple assembly pathways underlie amyloid-beta fibril polymorphisms./. Mol. Biol. 352, 282-298. 

Kellermayer, M. S., Grama, L., Karsai, A., Nagy, A., Kahn, A., Datki, Z. L., and Penke, B. (2005). Reversible mechanical unzipping of amyloid beta-fibrils./. Biol. Chem. 280, 8464-8470. 

Lashuel HA, Hartley DM, Balakhaneh D, Aggarwal A, Teichberg S, Callaway DJE. (2002) New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer s disease. J Biol Chem 111 42881 2890. 

In aged animal models, chronic administration of ginkgo for 3-4 weeks led to modifications in central nervous system receptors and neurotransmitters. Receptor densities increased for muscarinic, 2, and 5-HTla receptors and decreased for B-adrenoceptors. Increased serum levels of acetylcholine and norepinephrine and enhanced synaptosomal reuptake of serotonin have also been reported. Additional mechanisms that may be involved include reversible inhibition of MAO-A and MAO-B, reduced corticosterone synthesis, inhibition of amyloid-beta fibril formation, and enhanced GABA levels. 

Suppresses amyloid-beta fibrils formation and toxicity (neuroprotective)... 

Bieschke J, Russ J, Friedrich RP, Ehmhoefer DE, Wobst H, Neugebauer K, Wanker EE (2010) EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. Proc Natl Acad Sci USA 107(17) 7710-7715. doi 10.1073/pnas.0910723107, 0910723107 [pii]... 

Yang, F. et al., Cnrcnmin inhibits formation on amyloid beta oligomers and fibrils, binds plaqnes, and rednees amyloid in vivo, J. Biol. Chem., 280, 5892, 2005. 

Harper JD, Lieber CM, Lansbury PT Jr. Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer s disease amyloid-beta protein. Chem Biol 1997 4 951-959. 

Lomakin A, Chung DS, Benedek GB, Kirschner DA, Teplow DB. On the nucleation and growth of amyloid beta protein fibrils detection of nuclei... 

Terenius L, Nordstedt C. Controlling amyloid beta-peptide fibril formation with protease-stable ligands. J Biol Chem 1997 272 12601-12605. 

Van Nostrand WE, Melchor JP, Ruffini L. Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells. J Neurochem 1998 70 216-223. 

Nelson, R., Sawaya, M. R., Balbirnie, M., Madsen, A. O., Riekel, C., Grothe, R., and Eisenberg, D. (2005). Structure of the cross-beta spine of amyloid-like fibrils. Nature 435, 773-778. 

Lomakin, A., Chung, D. S., Benedek, G. B., Kirschner, D. A., and Teplow, D. B. (1996). On the nucleation and growth of amyloid beta-protein fibrils Detection of nuclei and quantitation of rate constants. Proc. Natl. Acad. Sci. USA 93, 1125-1129. 

Wang, W., and Hecht, M. H. (2002). Rationally designed mutations convert de novo amyloid-like fibrils into monomeric beta-sheet proteins. Proc. Natl. Acad. Sri. USA 99, 2760-2765. 

Lashuel, H. A., Petre, B. M., Wall, J., Simon, M., Nowak, R. J., Walz, T., and Lansbury, P. T., Jr. (2002). Alpha-synuclein, especially the Parkinson s disease-associated mutants, forms pore-like annular and tubular protofibrils./. Mol. Biol. 322,1089-1102. LeVine, H. (1993). Thioflavine T interaction with synthetic Alzheimer s disease beta-amyloid peptides Detection of amyloid aggregation in solution. Protein Sci. 2, 404—410. Lin, H., Bhatia, R., and Lai, R. (2001). Amyloid beta protein forms ion channels Implications for Alzheimer s disease pathophysiology. FASEB J. 15, 2433-2444. Lorenzo, A., and Yankner, B. A. (1994). Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl. Acad. Sci. USA 91, 12243-12247. Luhrs, T., Ritter, C., Adrian, M., Riek-Loher, D., Bohrmann, B., Dobeli, H., Schubert, D., and Riek, R. (2005). 3D structure of Alzheimer s amyl o id-( be la) (1—12) fibrils. Proc. Natl. Acad. Sci. USA 102, 17342-17347. 

Kirschner, D. A., Inouye, H., Duffy, L. K., Sinclair, A., Lind, M., and Selkoe, D.J. (1987). Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. USA 84, 6953-6957. 

Tjernberg, L. O., Callaway, D. J., Tjemberg, A., Hahne, S., Lilliehook, C., Terenius, L., Thyberg, J., and Nordstedt, C. (1999). A molecular model of Alzheimer amyloid beta-peptide fibril formation./ Biol. Chem. 274, 12619-12625. 

Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG Frautschy SA, Cole GM. (2005) Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 280 5892-5901. 

Inestrosa, N.C., Alvarez, A., Perez, C.A., Moreno, R.D., Vicente, M., Linker, C., Casanueva, O.I., Soto, C., Garrido, J. (1996). Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer s fibrils possible role of the peripheral site of the enzyme. Neuron 16 881-91. 

Sunde M, et al. Common core structure of amyloid fibrils by synchrotron X-ray diffraction. J. Molec. Biol. 1997 273 729. Tjemberg LO, et al. A molecular model of Alzheimer amyloid beta -peptide fibril formation. J. Biol. Chem. 1999 274 12619-12625. Benzinger TLS, et al. Two-dimensional structure of beta-Amyloid (10-35) fibrils. Biochem. 2000 39 3491-3499. 

Chen M, et al. Investigation of alpha-synuclein fibril structure by site-directed spin labeling. J. Biol. Chem. 2007 282 24970-24979. Schenk D, et al. Immunization with amyloid-(beta) attenuates Alzheimer-disease-Uke pathology in the PDAPP mouse. Nature 1999 400 173. 

Nelson R, et al. Structure of the cross-(beta) spine of amyloid-like fibrils. Nature 2005 435 773. 

Derivatives of Orcein, which is a phenoxazine dye that can be isolated from the lichen Roccella tinctoria, accelerate fibril formation of the amyloid-beta peptide. These compounds deplete oligomeric and protofibrillar forms of the peptide [244],... 

Sharoar MG, Thapa A, Shahnawaz M, Ramasamy VS, Woo ER, Shin SY et al (2012) Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates. J Biomed Sci 19 104... 

De Eerrari, G. V., Canales, M. A., Shin, 1., Weiner, L. M., Silman, 1., Inestrosa, N. C. A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation. Biochemistry, 2001, 40, 10447-10457. 

Alvarez, A., Alarcon, R., Opazo, C., Campos, E.O., Mujnoz, F.J., Calderon, F.H., Dajas, F., Gentry, M.K., Doctor, B.P., De Mello, F.G. and Inestrosa, N.C. (1998) Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer s fibrils. J Neurosci, 18, 3213-23. 

Ahmed M, Davis J, Aucoin D et al (2010) Stmctural conversion of neurotoxic amyloid-[beta] 1-42 oligomers to fibrils. Nat Stract Mol Biol 17 561-567... 

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