Amyloid beta Oligomers

Yang, F. et al., Cnrcnmin inhibits formation on amyloid beta oligomers and fibrils, binds plaqnes, and rednees amyloid in vivo, J. Biol. Chem., 280, 5892, 2005. 

Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG Frautschy SA, Cole GM. (2005) Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 280 5892-5901. 

Zhao, W.-Q., et al.. Amyloid beta oligomers induce impairment 52. of neuronal insulin receptors. FASEB J., 2008.22(l) p.246-260. 

Walsh DM, Klyubin 1, Fadeeva IV, Rowan Ml, Selkoe D1 (2002) Amyloid-beta oligomers their production, toxicity and therapeutic inhibition. Biochem Soc Trans 30 552—557 Wang J, GuUch S, Bradford C, Ramirez-Alvarado M, Regan L (2005) A twisted four-sheeted model for an amyloid fibril. Structure 13 1279-1288... 

Lahiri DK, Maloney B, Basha MR, Ge YW, Zawia NH (2007) How and when environmenud agents and dietary factors affect the course of Alzheimer s disease the LEARn model (latent early-hfe associated regulation) may explain the triggering of AD. Curr Alzheimer Res 4 219-228 Lauren J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM (2009) Cellultir prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457 1128-1132... 

Lacor, P., Buniel, M., Chang, L., Fernandez, S., Gong, Y., Viola, K., et al. Synaptic targeting by Alzheimer s-related amyloid beta oligomers. J. Neurosci. 45, 10191-10200 (2004)... 

Nogalska A, D Agostino C, Engel WK et al. (2010) Novel demonstration of amyloid-beta oligomers in sporadic inclusion-body myositis muscle fibers. Acta Neuropathol 120, 661-666. 

Zhao LN, Long H, Mu Y, Chew LY. The Toxicity of Amyloid beta Oligomers. Int J Mol Sci. 2012 13(6) 7303-7327. Shafrir Y, DureU S, Arispe N, Guy HR. Models of membrane-bound Alzheimer s Abeta peptide assemblies. 

Walsh, D.M., Klyubin, I., Fadeeva, J.V., Cullen, W.K., Anwyl, R., Wolfe, M.S., Rowan, M.J., and Selkoe, D.J., Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo, Nature, 416,535, 2002. 

Carlsson A, Lindquist M, Magnusson T (1957) 3-4 Dihydroxyphenylalanine and 5-hydroxy-tryptophanas reserpine antagonists. Nature 180 1200-12001 Castellani RJ, Nunomura A, Lee HG, Perry G, Smith MA (2008) Phosphorylated tau toxic, protective, or none of the above. J Alzheimers Dis 14(4) 377-383 Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH (2005) Natural oligomers of the amyloid-beta protein specifictilly dismpt cognitive function. Nat Neurosci 8(l) 79-84... 

Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ (2006) Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity a potent role fortrimers. J Physiol... 

Walsh DM, et al. Naturally secreted oligomers of amyloid (beta) protein potently inhibit hippocampal long-term potentiation in 40. vivo. Nature 2002 416 535. 

Cleai y JP, Walsh DM, Hofmeister JJ, Shankai GM, Kuskowski MA, Selkoe DJ, Ashe KH (2005) Natural oligomers of tlie amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci 8 79-84. 

Walsh DM, Klyubin I, Eadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan Ml, Selkoe DJ (2002) Natui ally secreted oligomers of amyloid beta protein potently inlribit liippocampal long-teim potentiation in vivo. Natui e 416 535—539. 

Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankai GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ (2005) Amyloid beta protein immunodierapy neuti alizes Abeta oligomers diat disi upt synapdc plasdcity in vivo. Nat Med 11 556-561. 

Sharoar MG, Thapa A, Shahnawaz M, Ramasamy VS, Woo ER, Shin SY et al (2012) Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates. J Biomed Sci 19 104... 

Malaplate-Armand, C., Florent-Bechard, S., Youssef, I., Koziel, V., Sponne, I., Kriem, B., Leininger-Muller, B., Olivier, J.L., Oster, T., and Pillot, T., Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyeli-nase-ceramide pathway, Neurobiol Dis, 23 (2006) 178-189. 

Ahmed M, Davis J, Aucoin D et al (2010) Stmctural conversion of neurotoxic amyloid-[beta] 1-42 oligomers to fibrils. Nat Stract Mol Biol 17 561-567... 

Luhrs T, Ritter C, Adrian M, Riek-Loher D, Bohrmann B, DobeU H, Schubert D, Riek R (2005) 3D structure of Alzheimer s amyloid-beta(1 2) fibrils. Proc Natl Acad Sci USA 102 17342-17347 Ma B, Nussinov R (2002) Molecular dynanfics simulations of alanine rich beta-sheet oligomers insight into amyloid formation. Protein Sci 11 2335-2350... 

Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration lessons from the Alzheimer s amyloid beta-peptide. Nat Rev Mol CeU Biol 8 101-112 Han X, Holtzmem DM, McKeel DW Jr (2001) Plasmalogen deficiency in etirly Alzheimer s disease subjects and in animtil models molecular characterization using electrospray ionization mass spectrometry. J Neurochem 77 1168-1180... 

Klyubin, L, Walsh, D.M., Lemere, C.A., et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat. Med. 11, 556-561 (2005).doi 10.1038/nml234... 

Stroud, J.C., Liu, C., Teng, P.K., Eisenberg, D. (2012) Toxic fibrillar oligomers of amyloid-beta have cross-beta structure. Proc Natl Acad Sci USA, 109 (20), 7717-7722. 

Kayed R, Sokolov Y, Edmonds B, et al. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. / Biol Chem. 2004 279(45) 46363-46366. Arispe N, Pollard FIB, Rojas E. Zn2+ interaction with Alzheimer amyloid beta protein calcium channels. Proc Natl Acad Sci USA. 19%,-93(4) 1710-1715. 

Alzheimer s Disease. Figure 1 A(3 monomers can self-associate to form dimers, trimers and higher oligomers. Globular structures of synthetic A(342 are known as A(3-derived diffusible ligands (ADDLs) (3-12-mers of A(3). These structures are similar to the smallest protofibrils and represent the earliest macromolecular assembly of synthetic A(3. The characteristic amyloid fiber exhibits a high beta-sheet content and is derived in vitro by a nucleation-dependent self-association and an associated conformational transition from random to beta-sheet conformation of the A(3 molecule. Intermediate protofibrils in turn self-associate to form mature fibers. 

Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM. (2009) Beta-amyloid oligomers induce phosphorylation of tan and inactivation of... 

Huang THJ, et al. Structural studies of soluble oligomers of the alzheimer (beta)-amyloid peptide. J. Molec. Biol. 2000 297 73. 

---