Aminoethyl methacrylate

Polyfructan (inulin) of MW 30-50 million was synthesized from sucrose with fructosyltransferase (FTF, inulin sucrase from Streptococcus mutans) immobilized by photoinitiated graft copolymerization with poly(2-aminoethyl methacrylate) in the pores of a 3.0 pm microfiltration membrane (Hicke, 1999). 

Recently, carboxyl- and amino-functionalized polystyrene latex particles were synthesized by the miniemulsion copolymerization of styrene and acrylic acid or 2-aminoethyl methacrylate hydrochloride (AEMH) [70, 71]. The reaction was started by using an oil-soluble initiator, 2,2 -azobis(2-methylbutyronitrile) (V-59). Two types of surfactant, i.e., ionic negatively charged SDS or positively charged CTMA-Cl, and nonionic Lutensol AT50 (which is a PEO hexadecyl ether with an EO block length of about 50 units) were used to stabilize the initial droplets and final particles. 

General. Aqueous solutions of hydrophilic monomers were emulsified in xylene using water-in-oil emulsifiers, and polymerized using oil-soluble initiators. Typical hydrophilic monomers were sodium p-vinylbenzene sulfonate, sodium vinylbenzyl sulfonate, 2-sulfoethyl acrylate, acrylic acid, acrylamide, vinylbenzyl-trimethylammonium chloride, and 2-aminoethyl methacrylate hydrochloride. Typical oil-soluble initiators were benzoyl and lauroyl peroxides. In some cases, water-soluble potassium persulfate was used, both separately and in mixtures with oil-soluble peroxides. Of the water-in-oil emulsifiers, one of the most effective was Span 60 (technical sorbitan monostearate. Atlas Chemical Industries, Inc.). 

To prepare water-soluble polymers employing CCT, it is necessary to modify the polymerization conditions.312 439 Use of a standard batch reaction leads to hydrolysis of catalyst, changing the catalyst level over the course of the polymerization, yielding a mixture of products and poor control of the reaction. A feed or starved-feed process that adds catalyst over the course of the reaction maintains a constant catalyst level and high conversion. The approach can be applied to a range of monomers such as methacrylic acid, 2-aminoethyl methacrylate hydrochloride, 2-hy-droxyethyl methacrylate, 2-methacryloxyethyl phos-phoryl choline, glycerol monomethyl methacrylate, and 3- O-methacryloyl-1,2 5,6-di- O-isopropylidene-D-glucofuranose. 

Carboxy- and amino-functionaUzed polystyrene nanoparticles have been synthesized by the miniemulsion process using styrene and the functional monomers acrylic acid (AA) or 2-aminoethyl methacrylate hydrochloride (AEMH) as functional comonomers [30,31]. By changing the amount of the comonomer, different surface densities of the charged groups could be realized. Since a fluorescent dye was incorporated inside the nanoparticles, the uptake behavior of different cell Unes could be determined as a function of the surface functionalization [30,31]. It was found that, in general, the uptake of the nanoparticles into the cells increases with increasing functionality on the particle s surface. For HeLa cells, for example, the internalized particle amount was up to sixfold better for carboxy-functionaUzed polystyrene (PS) nanoparticles than for non-functionalized PS particles. For amino functionalized PS nanoparticles, an up to 50-fold enhanced uptake could be detected. In order to investigate the actual uptake pathway into HeLa cells, positively... 

The conversion of the 2-aminoethyl methacrylate hydrochloride monomer to the free amino group in the polymer composite has been conducted completely which is clearly visible at the shift of the... 

Ji W, Panus D, Palumbo RN, Tang R, Wang C (2011) Poly(2-aminoethyl methacrylate) with well-defined chain length for DNA vaccine delivery to dendritic cells. Biomacromolecules 12 4373 385... 

Also in the field of hydrogels, (meth)acrylates play an important role. Since there is quite a number of hydrophilic methacrylate-based monomers available, radical copolymerization with an appropriate crosslinking monomer leads to network formation. The most widely used monomers are 2-hydroxyethyl methacrylate HEMA, 2-aminoethyl methacrylate and the alkyl derivatives, amethacrylamid and the alkyl derivatives, ethyleneglycol dimethacrylate EGDMA, and polyethyleneglycol dimethacrylate PEGDMA. 

Figure 4. Components of CLEAR supports trimethylolpropane ethoxylate triacrylate 9, 2-aminoethyl methacrylate 10 and poly(ethylene glycol-400) dimethylacrylate 11.

Carboxyl and amino-functionalized latex particles were synthesized [67] by the miniemulsion polymerization of styrene and acrylic acid or 2-aminoethyl methacrylate hydrochloride, and the effect of hydrophilic comonomer and surfactant type (nonionic versus ionic) on the colloidal stability, particle size, and particle size distribution was analyzed. The reaction mechanisms of particle formation in the presence of nonionic and ionic surfactants were proposed. 

Figure 8.1 Selective primary modification of carboxyl group on HA. AEMA 2-aminoethyl methacrylate hydrochloride ADH adipic acid dihydrazide APMA 2-aminoethyl methacrylate CDH carbodihydrazide HDMA hexane-1,6-diamine PDPH pyridyldithioethylamine SH thiol and VS vinyl sulfonyl...

Aminoethyl methacrylate lleOEt/AMPEG550 23.9-57.9 Chemically crossUnkable hydrogel Tunable mechanical gel property and the degradation rate [135-137]... 

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