Ethyleneglycol dimethacrylate

Monodispersed poly (methyl methacrylate-ethyleneglycol dimethacrylate) is prepared by a multistep swelling and polymerization method. When a good solvent such as toluene is applied as a porogen, the seed polymer severely affects the pore structure, whereas no effects are observed with poor solvents, such as cyclohexanol, as a porogen, in comparison with the conventional suspension polymerization (68,69). 

Hoffman and his coworkers have done a lot of work on the apphcation of radiation-induced graft polymerization for medical apphcation. The hydrophilic polymers that have been used for radiation-induced grafting are Al-vinyl pyrohdone (NVP), 2-hydroxyethyl methacrylate (HEMA), acrylamide (AAm), acrylic acid (AAc), glycidyl methacrylate (GMA), ethyleneglycol dimethacrylate (EGDMA), and ethyl methacrylate (EMA) onto sihcone rubber were widely smdied. 

Ayhan, F., Yousefi Rad, A., and Ayhan, H. (2002) Biocompatibility investigation and urea removal from blood by urease-immobilized HEMA incorporated poly(ethyleneglycol dimethacrylate) microbeads. J. Biomed. Mater. Res. B Appl. Biomat. 64B(1), 13-18. 

Haysep A 165 Divinylbenzene/ ethyleneglycol-dimethacrylate (high purity) 0.356 526... 

Materials. All monomers used for synthesis were free of inhibitors and freshly distilled 2-hydroxyethyl methacrylate (HEMA) dimethyl-acrylamide (DMA) N-vinylpyrrolidone (NPV) methylmethacrylate (MMA) 2-ethylhexylacrylate (EHA) isopropylmethacrylate (IPMA) n-butyl-acrylate (BA) ethyleneglycol-dimethacrylate (EGDMA) dimethacrylate macromer obtained by reaction of 1 mol polytetramethylene oxide diol (MW 2000) with 2 mol 2,4,4-trimethyl-l,6-diisocyanatohexane and 2 mol HEMA (PX). ... 

An additional porous polymer is poly(glycidyl methacrylate-ethyleneglycol dimethacrylate) (see Figure 2.46) that is synthesized by suspension polymerization in the presence of an inert porogen in the polymerization reaction, obtaining a material with an internal macroporous morphology characterized by an interconnected pore network, which permeates the extensively cross-linked polymer matrix [209],... 

FIGURE 2.46 Poly(glycidyl methacrylate-ethyleneglycol dimethacrylate) copolymer. 

Ordered mesoporous polymers have been produced by filling with divinylbenzene, ethyleneglycol dimethacrylate, or a mixture of the two the pores of a colloidal crystal are formed by silica spheres of 35 nm of diameter. Thereafter, the polymerization and subsequent dissolution of the silica template leave a polycrystalline network of interconnected pores [235],... 

Conventionally, MlPs are obtained by bulk co-polymerization from a mixture consisting of a functional monomer, cross-linker, chiral template, and a porogenic solvent mixture. Nowadays, imprinting via non-covalent template binding is preferred over the covalent mode and involves three major steps (see Fig. 9.9). (i) Functional monomers (e.g. methacrylic acid, MAA) and a cross-linker (e.g. ethyleneglycol dimethacrylate, EDMA) assemble around the enantiomeric print molecule, e.g. (S)-phenylalanine anilide (1), driven by non-covalent intermolecular interactions, e.g. ionic interactions, hydrogen bonding, dipole-dipole interaction. Tr-rt-interaction. (ii) By thermally or photochemi-... 

By far the most used systems are matrices based on methacrylate, methacrylamide and styrene and the most common crosslinkers are ethyleneglycol dimethacrylate and divinylbenzene. Methacrylamide based species are the most hydrophilic and styrene ones the most hydrophobic, with the methacrylate systems falling in between. This therefore provides quite a wide choice and imprinted polymers with high mechanical stability and chemical inertness, suitable for example in HPLC applications, are readily achievable. To some extent the chemical nature of the matrix is of less importance than its morphology, and in this respect the type and level of crosslinker used, together with the nature and proportion of the porogen are more crucial (see later). All of these experimental parameters are of course inter-dependent. 

Poly(S -benzoyl O-ethylmethacrylate xanthate) resin [poly(BEMX)], obtained by functionalization of crosslinked 2-hydroxyethyl methacrylate/ethyleneglycol dimethacrylate beads, results [135], upon irradiation at 400 nm, in a heterogeneous photoinitiator for the polymerization of MMA and styrene more effective than the low-molecular-weight analogue BEX. 

The template, the functional monomers and the cross-linking monomers are dissolved in a non-polar solvent. The functional monomers and the template form complexes and the strength of these are reflected in the selectivity of the imprinted polymer. The choice of functional monomer is based on the template structure. Functional monomers are chosen for their ability to interact non-covalently with the template molecule. The most frequently used functional monomer so far is methacrylic acid (MAA). Also vinylpyridines have been frequently used. As cross-linking monomers, ethyleneglycol dimethacrylate (EDMA) or trimethylolpropane trimethacrylate (TRIM) are widely used. Several other types of functional and cross-linking monomers have been used in molecular imprinting experiments using the non-covalent approach. The choice of monomers is of course important to the... 

Davis, T.P. Huglin, M.B. Yip, D.C.F. Properties of poly(V-vinyl-2-pyrrolidone) hydrogels crosslinked with ethyleneglycol dimethacrylate. Polymer 1988, 29, 701-706. 

Scheme 3 Noncovalent imprinting of L-phenylalanine methyl ester in a methacrylic acid (MAA)/ethyleneglycol dimethacrylate (EDMA) polymer matrix. (View this art in color at www.dekker.com.)...

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