Amino hydrochloride water solutions

Acid anhydrides, 391 Amino hydrochloride water solutions, lyotropic phases, 306-308,310/ Amorphous polyimide-liquid-crystalline polyamide composites. See Liquid-crystalline polyamide-amorphous polyimide composites Amphiphilic liquid crystal(s), establishment, 235,236/... 

Then, as described in U.S. Patent 3,158,648, the optical isomers may be resolved as follows. 37 g of racemic a-methYl-3,4-dihYdroxYphenylalanine are slurried at 35°C in 100 cc of 1.0 N hydrochloric acid. The excess solids are filtered leaving a saturated solution containing 34.6 g of racemic amino acid of which about 61% is present as the hydrochloride. The solution Is then seeded at 35°C with 7 g of hydrated L-o -methYl-3,4-dihYdroxYphenYlalanine (6.2 g of anhydrous material). The mixture is then cooled to 20°C in 30 minutes and aged one hour at 20°C. The separated material Is isolated by filtration, washed twice with 10 cc of cold water and dried in vacuo. The yield of product is 14.1 g of L-a-methYl-3,4-di-hydroxyphenylalanine in the form of a sesquihydrate of 100% purity as determined by the rotation of the copper complex. 

Glutamic acid has been prepared from the hydrochloride by treating a water solution with strong alkalies,2 alkali carbonates,3 and ammonium hydroxide.4 Hopkins 5 has shown that the addition of 6-8 volumes of alcohol to a concentrated water solution of glutamic acid hydrochloride will cause a slow precipitation of the free amino acid. 

Exercises in thin-layer chromatography. Separation of amino acids. Prepare solutions of DL-alanine, L-leucine and L-lysine hydrochloride by dissolving 5 mg of each separately in 0.33 ml of distilled water, measured with a graduated 1 ml pipette (leucine may require warming to effect solution). Mix one drop of each solution to provide a mixture of the three amino acids and dilute the remainder of each solution to 1 ml to give solutions of the respective amino acids. The latter will contain about 5 pg of each amino acid per pi. Apply approximately 0.5 pi of each of the solutions to a Silica Gel G plate and allow to dry in the air (i.e. until the spots are no longer visible). 

A typical three-compartment ED stack using bipolar, cationic, and anionic membranes (Figure 8A) was patented by Mani (2000) to produce lysine hydrochloride. By feeding the salt compartments with a salt (e.g., NaCl, KC1, or LiCl) solution, the base and acid ones with water and a lysine-rich solution, respectively, the salt can be split into an alkali and hydrochloric acid. The latter reacts with lysine, thus yielding the amino hydrochloride. 

Intriguingly, some of the properties of LMWGs, such as biodegradabihty, biocompatibility, and gende physical and chemical profiles, represent considerable potential in the fields of biomedicinal applications and drug delivery [58-62]. For this purpose, amphiphilic 3,4,5-trihydroxybenzoic derivatives with linkers of different lengths (26a, 26b, Fig. 3.23) were developed by us [63]. The compounds 26a and 26b with two naked -COOH are able to gel in aqueous ethanol, meanwhile, they can trap a great amount of tetracycline hydrochloride (TH) in gel tissue. In the presence of BSA or amino acids, TH could be controUably released into water solution. 

The Os(VIII)-catalysed alkaline oxidation of guanidine hydrochloride by 104 ions is of fractional order in OH and zero order in substrate. The rate law for Mn(n)-catalysed oxidation of 2-amino-meto-xylene to 2,6-dimethyl-pura-benzoquinone in acetone-water solution has a complex dependence in H+ the rates decrease on increasing the ionic strength and decreasing the dielectric constant of the medium. The oxidation of myo-inositol has been studied in both alkaline and acidic solution and found to exhibit inverse fractional order in H" " and OH ions the alkaline reaction has an inverse fractional order in the substrate, whereas a fractional order is observed in the acidic reaction. The Ru(III)-catalysed oxidation of 2-methylcyclohexanol (mch) to 2-methylcyclohexan one in HCIO4 is zero order in mch and H" " ions. The rate of oxidation of L-serine to 2-hydroxyethanal in alkaline medium is retarded by OH ions and the ionic strength. ... 

Bromo-4-aminotoluene, Suspend the hydrochloride in 400 ml, of water in a 1-Utre beaker equipped with a mechanical stirrer. Add a solution of 70 g. of sodium hydroxide in 350 ml. of water. The free base separates as a dark heavy oil. After cooUng to 15-20°, transfer the mixture to a separatory funnel and run off the crude 3-bromo-4-amino-toluene. This weighs 125 g. and can be used directly in the next step (3). 

Dissolve 5 g. of finely-powdered diazoaminobenzene (Section IV,81) in 12-15 g. of aniline in a small flask and add 2-5 g. of finely-powdered aniline hydrochloride (1). Warm the mixture, with frequent shaking, on a water bath at 40-45° for 1 hour. Allow the reaction mixture to stand for 30 minutes. Then add 15 ml. of glacial acetic acid diluted with an equal volume of water stir or shake the mixture in order to remove the excess of anihne in the form of its soluble acetate. Allow the mixture to stand, with frequent shaking, for 15 minutes filter the amino-azobenzene at the pump, wash with a little water, and dry upon filter paper Recrystallise the crude p-amino-azobenzene (3-5 g. m.p. 120°) from 15-20 ml. of carbon tetrachloride to obtain the pure compound, m.p. 125°. Alternatively, the compound may be recrystaUised from dilute alcohol, to which a few drops of concentrated ammonia solution have been added. 

To prepare the hydrochloride, dissolve about 1 g. of the compound (which need not be perfectly dry) in about 8 ml. of alcohol. Add this solution to boiling dilute hydrochloric acid (10 ml. of the concentrated acid and 80 ml. of water). Boil for 5 minutes, filter the hot solution if necessary, and allow to cool. p-Amino-azobenzene hydrochloride separates in steel-blue crystals. Filter, wash with a little dilute hydrochloric acid, and dry. 

To recover the free base, dissolve the hydrochloride in the minimum volume of boiling alcohol, add concentrated ammonia solution dropwise until a clear solution results and the blue colour has become fight brown. Add water carefully untU a cloudiness appears, warm on a water bath untU the cloudiness just disappears, and allow to cool. Yellow crystals of p-amino-azobenzene separate on coofing. 

Phenylpropanolamine. - With catalyst prepared as previously described from 0.5g of palladium chloride and 3g of charcoal, it was possible to reduce two portions of 9.8g of isonitrosopropio-phenone (0.06 mol), dissolved in 150 cc. of absolute alcohol containing 7. Og of hydrogen chloride, to phenylpropanolamine in from 145 - 190 minutes with yields of the isolated chloride from 9.4g to 11. Og, or 84 to 98% of the theoretical. After recrystallization from absolute alcohol the salt melted at 191°. The free base was obtained by treating an aqueous solution of the hydrochloride with alkali on cooling, the liberated amino alcohol solidified and after recrystallization from water melted at 103°."... 

Amino-2-hydroxybenZOiC acid. This derivative (18) more commonly known as 4-aminosa1icy1ic acid, forms white crystals from ethanol, melts with effervescence and darkens on exposure to light and air. A reddish-brown crystalline powder is obtained on recrystallization from ethanol —diethyl ether. The compound is soluble ia dilute solutioas of nitric acid and sodium hydroxide, ethanol, and acetone slightly soluble in water and diethyl ether and virtually insoluble in benzene, chloroform or carbon tetrachloride. It is unstable in aqueous solution and decarboxylates to form 3-amiaophenol. Because of the instabihty of the free acid, it is usually prepared as the hydrochloride salt, mp 224 °C (dec), dissociation constant p 3.25. 

The 2-amino-selenazoles are crystalline compounds, and sometimes unstable, for example, the parent compound on heating in water undergoes complete decomposition. A few of these selenazoles which are substituted in the amino group are oily liquids. The basic character is more pronounced than in the alkyl- and aryl-selenazoles. The hydrochloride salts are, therefore, not so easily hydrolyzed in aqueous solution. 2-Amino- and 2-methylamino-4-methylselenazole have been considered to exist partly in the tautomeric selenazol-2-one imine form from comparison of their ultraviolet spectrum with that of 2-diethylamino-4-methylselenazole. ... 

Preparation of 7-amino-3-chloro-3-cephem-4-carboxylic acid To a solution of 750 mg (1 55 mmol) of p-nitrobenzyl 7-amino-3-chloro-3-cephem-4-carboxylate hydrochloride in 20 ml of tetrahydrofuran and 40 ml of methanol was added a suspension of 750 mg of prereduced 5% palladium on carbon catalyst in 20 ml of ethanol and the suspension was hydrogenated under 50 psi of hydrogen at room temperature for 45 minutes. The catalyst was filtered and washed with THF and water. The filtrate and catalyst washes were combined and evaporated to dryness. The residue was dissolved in a water-ethyl acetate mixture and the pH adjusted to pH 3. The insoluble product was filtered and triturated with acetone. The product was then dried to yield 115 mg of 7-amlno-3-chloro-3-cephem-4-carboxylic acid. 

Step H Preparation of 4-fOrtho-(2, 3 -Dihydroxypropyloxycarbonyl)-PhenylJ-Amino-S-Trifluoromethylquinoline — Into a mixture of 60 cc of water and 12 cc of aqueous solution of 22°Be hydrochloric acid there was introduced 19.8 grams of 4-[ortho-(2, 3 -dihy-droxypropyloxycarbonyll-phenyl] -amino-8-trifluoromethylquinoline acetonide (obtained in Step G) and the temperature of the reaction mixture was raised to 95°C and maintained at this temperature for 15 minutes. The mixture was cooled to 0°C and crystallization was allowed. The crude hydrochloride was recovered by filtration, washed and introduced into a mixture of 60 cc of dimethylformamide, 40 cc of water and 10 cc of triethylamine. 

N sodium hydroxide solution (5 ml) is added to a stirred suspension of S-methyllsothiosemi-carbazide hydroiodide (2.33 g) and hydroxylamine hydrochloride (0.70 g) In water (6 ml) and stirred for 48 hours. The solution is evaporated In vacuo to provide 1 -amino-3-hydroxy-guanidine. One-third of the residue is dissolved in 16 ml of ethanol and 2,6-dichlorobenzalde-hyde (0.6 g) Is added to this solution. The reaction mixture is then stirred for 48 hours. The solution is then evaporated in vacuo and the residue dissolved in ether (30 ml) and in hydrochloric acid (30 ml). The aqueous phase is rendered alkaline with 2 N sodium carbonate solution and extracted with ether. The ether layer is dried with sodium sulfate and evaporated. 

A) 1-(2-Amino-5-chlorophenyll-1-(2-fluorophenyll-2-a2a-but-1-en-4-ol A mixture of 40 g of 2-methylimidazole hydrochloride and of 90 g of 2-amino-5-chloro-2 -fluoro-benzophenone in 240 ml of ethanolamine is heated at 135 for 2 hours. After cooling, the reaction mixture is poured into an aqueous sodium bicarbonate solution. The mixture is extracted with ether, the organic phase is washed repeatedly with water and is dried over sodium sulfate, and the solvent is evaporated to dryness. The residual oil is chromatographed on a silica column, elution being carried out with a 50/50 mixture of cyclohexane and ethyl acetate. 

The combined liquors, which comprise an aqueous hydrochloric acid solution of 3-amino-methyl-pyridine hydrochloride, are then heated to a temperature of 60° to 65°C, and ethyl nitrite gas is passed into the heated solution. The ethyl nitrite is generated by placing 20 liters of 90% ethyl alcohol in a suitable vessel, diluting with 200 liters of water, and, while stirring, adding to the dilute alcohol 18.3 kg of nitrosyl chloride at the rate of 2.25 kg per hour. (The process using methyl nitrite is carried out by substituting a stoichiometrically equivalent quantity of methyl alcohol for the ethyl alcohol.)... 

Step 4 A solution of 20 grams of the above amino alcohol is dissolved in 50 ml of dry chloroform and treated with dry hydrogen chloride until acid. Then a solution of 9 grams of thionyi chloride in 50 ml of dry chloroform is added and the reaction mixture is heated on a water bath at 50°-60°C for 2 hours. Most of the chloroform is removed by distillation under reduced pressure. Addition of ether to the residue causes the product to crystallize. After recrystallization from a mixture of alcohol and ether, the N-(phenoxyisopropyl)-N-benzyl-0-chloroethylamine hydrochloride melts at 137.5°-140°C. 

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