Epigastric distress

The incidence of adverse reactions appears to be higher when larger doses of isoniazid are prescribed. Adverse reactions include hypersensitivity reactions, hematologic changes, jaundice, fever, skin eruptions, nausea, vomiting, and epigastric distress. Severe, and sometimes fatal, hepatitis has been associated witii isoniazid tiierapy and may appear after many months of treatment. Peripheral neuropathy (numbness and tingling of the extremities) is the most common symptom of toxicity. 

Nausea, vomiting, epigastric distress, heartburn, fatigue, dizziness, rash, hematologic changes, and renal insufficiency may be seen witii administration of rifampin. Rifampin may also cause a reddish-orange discoloration of body fluids, including urine, tears, saliva, sweat, and sputum. 

Some antihistamines may cause dizziness, disturbed coordination, fatigue, hypotension, headache, epigastric distress, and photosensitivity (exaggerated response to brief exposure to the sun, resulting in moderately severe to severe sunburn). 

Trimethoprim (Trimpex) interferes with the ability of bacteria to metabolize folinic acid, thereby exerting bacteriostatic activity. Trimethoprim is used for UTIs that are caused by susceptible microorganisms. Trimethoprim administration may result in rash, pruritus, epigastric distress, nausea, and vomiting. When trimethoprim is combined with sulfamethoxazole (Septra), the adverse effects associated with a sulfonamide may also occur. The adverse reactions seen with other anti-infectives, such as ampicillin, the sulfonamides, and cephalosporins, are given in their appropriate chapters. 

Other side effects include loss of appetite, nausea, vomiting, and epigastric distress. Taking medication with meals or a full glass of water may prevent GI side effects. 

Gl Nausea and vomiting anorexia epigastric distress diarrhea flatulence dysphagia increased salivation stomatitis glossitis parotid swelling abdominal cramps pancreatitis black tongue. 

Systemic- Headache salivation Gl cramps vomiting diarrhea asthma syncope cardiac arrhythmia flushing sweating epigastric distress tightness in bladder hypotension frequent urge to urinate. 

Itraconazole is usually well tolerated but can be associated with nausea and epigastric distress. Dizziness and headache also have been reported. High doses may cause hypokalemia, hypertension, and edema. Itraconazole, unlike ketoconazole, is not associated with hormonal suppression. Hepatotoxicity occurs in fewer than 5% of cases and is usually manifested by reversible Uver enzyme elevations. 

Nausea, vomiting, and anorexia occur commonly with ketoconazole, especially when high doses are prescribed. Epigastric distress can be reduced by taking ketoconazole with food. Pruritis and/or allergic dermatitis occurs in 10% of patients. Liver enzyme elevations during therapy are not unusual and are usually reversible. Severe ketoconazole-associated hepatitis is rare. 

When 5-FC is prescribed alone to patients with normal renal function, skin rash, epigastric distress, diarrhea, and liver enzyme elevations can occur. When it is prescribed to patients with renal insufficiency or to patients receiving concurrent amphotericin B therapy, blood levels of 5-FC may rise, and bone marrow toxicity leading to leukopenia and thrombocytopenia is common. 5-FC serum levels should be closely monitored in patients with renal insufficiency. Because of baseline leukopenia, 5-FC is often not tolerated by end-stage HIV-infected patients with disseminated fungal infection. 

Dyspepsia (heartburn, epigastric distress), fatigue, pruritus, hypotension Serious Reactions... 

Epigastric distress, flushing, blurred vision, tinnitus, paresthesia, sweating, chills Serious Reactions... 

Epigastric distress, flushing, visual or hearing disturbances, paresthesia, diaphoresis, chills... 

Back pain dyspepsia, including epigastric distress and heartburn peripheral discomfort diarrhea headache myalgia Occasional (4%-3%)... 

Overdosage includes symptoms of abdominal cramps, vomiting, burning epigastric distress, central nervous system and cardiovascular disturbances, cyanosis, methemoglobinemia, moderate leukocytosis or leukopenia, and anemia. 

Pharyngitis, headache, diarrhea, dyspepsia, including heartburn and epigastric distress, nausea Rare (less than 3%)... 

Epigastric distress, anorexia, vomiting, headache, dizziness, red-brown or darkened urine... 

Mania (12%-6%) Asthenia, abdominal pain, dyspepsia (heartburn, indigestion, epigastric distress), rash Rare... 

It is dextro isomer of propoxyphene which is an analgesic and possesses antitussive property. It has low analgesic activity even half of codeine. It is metabolized in Uver. Side effects include vomiting, epigastric distress and sedation. The demethylated metabolite of propoxyphene is cardiotoxic. It is used in the treatment of mild type of pain. 

Adverse effects include nausea, epigastric distress, aplastic anaemia, vomiting, diarrhoea, peptic ulcer, depression, neutropenia, hypothyroidism, skin rash and urticaria. 

Adverse effects include nausea, vomiting, anorexia, gastric bleeding, diarrhoea, dizziness, frontal headache, confusion, depression, psychosis, hallucination, leukopenia, epigastric distress and rarely aplastic anaemia. 

Adverse effects include, nausea, vomiting, epigastric distress, skin rash, rarely haematuria, proteinuria, hepatitis and depression. 

Side effects include epigastric distress, nausea and impaired alertness. 

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