Allergic inflammatory disease

Control and Regulation of Peripheral Tolerance in Allergic Inflammatory Disease Therapeutic Consequences... 

Chemokine accumulation occurs in autoimmune degenerative disease such as multiple sclerosis and in allergic inflammatory diseases such as asthma. Various viruses produce CH antagonists that interfere with the CH-mediated defence system and HIV-1 infects cells via the CCR5 receptor. 

Nerve growth factor expression and release in allergic inflammatory disease of the upper airways. Am J Respir Crit Care Med 161 1631-1635 Shim WS, Tak MH, Lee MH, Kim M, Kim M, Koo JY, Lee CH, Kim M, Oh U (2007) TRPVl mediates histamine-induced itching via the activation of phospholipase A2 and 12-Lipoxygenase. JNeurosci 27 2331-2337... 

Indications for the clinical use of immunosuppressive drugs are transplantation, autoimmune diseases, chronic inflammatory diseases, allergic reactions. 

Allergic reactions (especially those of type IV) can lead to disorders which resemble autoimmune or chronic inflammatory diseases. If an immediate elimination of the antigen is not feasible, immunosuppressive drugs can represent a reasonable addendum. 

These compounds represent only some of the efforts being made to target the TLRs and their signalling pathways. Targeting TLRs holds great promise in the effort to find new therapies for infectious, allergic and inflammatory diseases, and cancer. 

Allergic rhinitis A highly prevalent, allergen-induced, upper airway inflammatory disease characterized by chronic hyperreactive airway mucosa with periods of acute exacerbations. 

Fig.l. Expression of CC and CXC chemokine receptors by inflammatory and structural cells in allergic lung disease. Eos, eosinophil Mac, macrophage Mono, monocyte. 

Exploiting the knowledge that has recently developed on the induction of regulatory immune pathways by helminths, clinical trials were and are being initiated to study the effect of these parasites on inflammatory diseases. Currently, Trichuris suis is being used to treat patients with ulcerative colitis and Crohn s disease, with promising initial results [44]. Future studies are planned to examine the effect of hookworms on allergic airway diseases [45] and of T. suis on MS [11]. 

Glucocorticoids are widely used as drugs to treat arthritis and dermatitis. In pharmacological doses, they are used to suppress various allergic, inflammatory and autoimmune diseases. They are also administered as post-transplant immunosuppressants. Nevertheless, they do not prevent infection and they also inhibit subsequent regenerative processes. Excessive glucocorticoid levels have side effects on many systems, such as the inhibition of bone formation, delayed wound healing, muscle weakness and an increased risk of infection. 

Special interest in the prostaglandins has focused on pain of inflammation and allergic responses. The medical significance is easy to see. Five million Americans have rheumatoid arthritis, an inflammatory disease. Bronchial asthma and other allergic diseases are equally important. Our most common medicine is aspirin, an anti-inflammatory drug. Both the inflammatory response and the immune response are normal parts of the defense mechanisms of the body, but both are potentially harmful, and it is their regulation that is probably faulty in rheumatoid arthritis and asthma. Overproduction of prostaglandins may be a cause of menstrual cramps.308... 

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