Allergic Airways Diseases

Chung CD, Kuo F, Kumer J, et al. CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease. J Immunol 2003 170 581-587. 

Goya I, Villares R, Zaballos A, et al. Absence of CCR8 does not impair the response to ovalbumin-induced allergic airway disease. J Immunol 2003 170(4) 2138-2146. 

Blease K, Mehrad B, Standiford TJ, et al. Airway remodeling is absent in CCRI mice during chronic fungal allergic airway disease. J Immunol 2000 ... 

John AE, Gerard CJ, Schaller M, et al. Respiratory syncytial virus-induced exaggeration of allergic airway disease is dependent upon CCRI-associated immune responses. Eur J Immunol 2005 35(1) 108-116. 

De Haar, C., et al., Ultrafine carbon black particles cause early airway inflammation and have adjuvant activity in a mouse allergic airway disease model, Toxicol. Sci. 87, 2, 409, 2005. 

We and others have been able to develop mouse and rat models of allergic airways disease that exhibit shifts in DRC to bronchoconstrictor... 

Mast cell-derived tumour necrosis factor is essential for allergic airway disease. Eur Respir J 2008 31 773-782. 

Exploiting the knowledge that has recently developed on the induction of regulatory immune pathways by helminths, clinical trials were and are being initiated to study the effect of these parasites on inflammatory diseases. Currently, Trichuris suis is being used to treat patients with ulcerative colitis and Crohn s disease, with promising initial results [44]. Future studies are planned to examine the effect of hookworms on allergic airway diseases [45] and of T. suis on MS [11]. 

Xanthou G. Alissafi T, Semitekolou M, Simoes DC. Economidou E. Gaga M, Lambrecht BN. Lloyd CM. Panoutsakopoulou V Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nat Med 2007 13 570-578. 

Beclometasone dipropionate is the most widely dispensed inhaled anti-inflammatory agent for astfunatic human patients. Inhaled beclometasone dipropionate reduces inflammatory cell populations in bronchoalveolar lavage fluid, controls clinical signs of airway obstruction and improves parameters of pulmonary function in human asthmatics. Consequently, aerosolized beclometasone dipropionate is the first line of therapy for mod-erate-to-severe allergic airway disease in human patients. Aerosolized beclometasone does not cause adrenal suppression in asthmatic human patients at therapeutic dosages (800-1600 xg/day) and initiation of beclometasone therapy as a replacement for systemic corticosteroid administration permits recovery of the hypothalamic-pituitary-adrenal axis (Barnes et al 1998). 

Bertrand. C. er al. (1996) Tachykinin and kinin receptor antagonists therapeutic perspectives in allergic airway disease. Trends Pharmacol. Scf. 17.255-259. 

Diaz-Sanchez D. The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease. Allergy 1997 52(Suppl 38) 52-6. 

Gavett SH, Haykal-Coates N, Copeland LB, et al. Metal composition of ambient PM 2.5 influences severity of allergic airways disease in mice. Environ Health Perspect 2003 111(12) 1471—7. 

They do not exhibit the cardiac stimulatory properties of theophylline. In addition, to bronchodilator action, compound II possesses, as predicted from its tricyclic structure, antihlstamlnlc and possibly even some mediator release inhibitor properties which could compliment its overall utility in allergic airways disease. 

In a recent review (103), Gutierrez-Ramos et al. studied chemokine and chemokine receptor expression in detail during the development of a mouse model of allergic airway disease (AAD), and it was found that during the development of inflammatory reaction, different chemokines and receptors operate in a coordinate manner by differential temporal and spatial expression. 

Epidemiological studies suggest that phthalate plasticizers m possess adjirvant effect and, thus, may promote development of allergic airway diseases. Recent studies in arri-mals demonstrated that several of the commonly used phthalate plasticizers were adjuvants although their potentials as adjrrvants varied. The adjuvant effect observed in the animal studies occttrred with concentratiorrs which were at the same levels as observed for... 

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