Allergic lung disease

Lindell DM, Berlin AA. Schaller MA. Lukacs NW B-cell antigen presentation promotes Th2 responses and immunopathology during chronic allergic lung disease. PLoS ONE 2008 3 e3129. 

Fig.l. Expression of CC and CXC chemokine receptors by inflammatory and structural cells in allergic lung disease. Eos, eosinophil Mac, macrophage Mono, monocyte. 

Expression of Chemokine Receptors by Leukocytes and Structural Cells in Allergic Lung Disease... 

Note +, expressed by cell type ++, evidence for role in allergic lung disease. 

In the live Aspergillus model of allergic lung disease, CXCR2 / mice had fewer eosinophils and T cells (but interestingly similar neutrophil numbers). These were accompanied by decreased lung levels of IL-4, IL-5, and CCL11... 

Respiratory allergies and infections are the most common form of illness in the United States and Europe and account for more missed school and work days than any other disease [1], A substantial body of experimental work has clearly shown that airborne toxicants such as tobacco smoke, ozone, and other air pollutants can alter many aspects of the host defense network to either decrease resistance to infection, or exacerbate respiratory allergies and asthma [2], Exposure to air toxicants can suppress a number of key host defenses including mucociliary clearance in the airways, pulmonary macrophage function, and development of specific immune responses such as IgG antibody production and cell mediated immunity. In contrast, immune stimulation in the form of increased T cell activity and IgE antibody formation has also has been shown to occur under some circumstances, resulting in increased incidence or severity of allergic lung disease. 

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