Alcohol, Urinary

Selenium status is also adversely affected by chronic ethanol intake. Recently, Dutta et aL (1983) showed a significant depression in plasma selenium levels in hospitalized alcoholics. Urinary excretion was also low in these subjects, who were otherwise well nourished. The authors pointed out that alcoholic beverages contain very low levels of selenium. Several investigators have demonstrated that in the selenium-deficient animal, hepatic preneoplastic foci development is enhanced (O Connor et aL, 1983 O Connor and Campbell, 1984). Ethanol could thus indirectly enhance tumor development by depleting selenium stores. 

Another factor that impacts urinary steroid profiles is the acute consumption of alcohol.Urinary T/EpiT values increase and A/T levels decrease under the influence of ethanol intake, which necessitates analyses for ethanol (and/or its glucuronic acid conjugate) in urine samples being suspect due to the above mentioned alterations in the steroid profile. ... 

The energy substrates are contraindicated in patients with hypersensitivity to any component of the solution. Dextrose solutions are contraindicated in patients with diabetic coma with excessively high blood sugar. Concentrated dextrose solutions are contraindicated in patients with increased intracranial pressure, delirium tremens (if patient is dehydrated), hepatic coma, or glucose-galactose malabsorption syndrome Alcohol dextrose solutions are contraindicated in patients with epilepsy, urinary tract infections, alcoholism, and diabetic coma... 

If the test is positive, the urine is examined microscopically for red blood cells. If no red blood cells are found, a tentative diagnosis of myoglobinuria is made, serum chemistries are obtained, and the patient is held to rule out rhabdomyolysis. If the uric acid and creatinine kinase (CK) values are normal, and the patient is asymptomatic, he/she is discharged from the hospital. Routine toxicology tests include urinary PCP, serum alcohol, and hypnotic screen. 

O Primary peritonitis develops in up to 25% of patients with alcoholic cirrhosis.3 Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) average one episode of peritonitis every 2 years.4 Secondary peritonitis may be caused by perforation of a peptic ulcer traumatic perforation of the stomach, small or large bowel, uterus, or urinary bladder appendicitis pancreatitis diverticulitis bowel infarction inflammatory bowel disease cholecystitis operative contamination of the peritoneum or diseases of the female genital tract such as septic abortion, postoperative uterine infection, endometritis, or salpingitis. Appendicitis is one of the most common causes of intraabdominal infection. In 1998, 278,000 appendectomies were performed in the United States for suspected appendicitis.5... 

The metabolic fate of chlordan was studied in rabbits by analysis of the relative chlorine content of chlordan added to normal rabbit s urine and of the chlorine content of the urinary excretory product. The method of analysis was similar to the one previously used (, 4) In addition, hydrolysis of chlordan and of the urinary excretory products was carried out by adding solid sodium hydroxide to saturation to a 10-ml. solution of these substances in hot absolute ethyl alcohol. The mixture was refluxed for 3 hours in a round-bottomed flask immersed in boiling water and the amount of inorganic chlorine determined. Hydrolysis was similarly carried out with solutions of the respective substances in aqueous sodium hydroxide. 

Behavioral observations of male white-tailed deer indicate that urine could play a role in olfactory communication in this animal [131]. To extend the knowledge of the urinary volatiles of the white-tailed deer and to investigate the possibility that vaginal mucus could also carry semiochemical information, Jemiolo et al. [132] studied the qualitative and concentration changes in the profiles of the volatiles present in these excretions. Forty-four volatiles were found in the mucus and 63 in female urine. The volatiles common to both vaginal mucus and urine included alcohols, aldehydes, furans, ketones, alkanes, and alkenes. Aromatic hydrocarbons were found only in the mucus, whereas pyrans, amines, esters and phenols were found only in the urine. Both estrous mucus and estrous urine could be identified by the presence of specific compounds that were not present in mid-cycle samples. Numerous compounds exhibited dependency on ovarian hormones. 

In one study we explored sixty items in a small group of alcoholics and nonalcoholic controls in the hopes of finding some metabolic peculiarities which might be associated with alcoholism-proneness.2 These sixty items included urinary constituents, salivary constituents, and blood constituents. There were six items which appeared to be significantly different for the two groups. Subsequently, more extensive investigations have indicated that certain of these items are, with even higher probability, distinctively different for alcoholics.3... 

In conclusion, the oxamic acid derivative is produced by two distinct metabolic pathways, namely by oxidative and hydrolytic dechlorinations. In contrast, the primary alcohol metabolite 11.41 can be produced only by hydrolytic dechlorination and is, thus, an unambiguous marker of this pathway. The alcohol 11.41 is a known urinary metabolite of chloramphenicol in humans. 

Alcoholics can also develop ketoaddosis. In alcoholic ketoacidosis, 3-hydroxybutyrate is the major ketone body produced because there is usually a high NADH/NAD ratio in the hver. The urinary nitroprusside test detects only acetoacetate and may dramatically underestimate the extent of ketosis in an alcoholic. 3-Hydroxybutyrate levels (P-hydroxybutyrate) should always be measured in these patients. 

A mammal may emit many volatile compounds. Humans, for instance, give off hundreds of volatiles, many of them chemically identified (Ellin etal., 1974). The volatiles include many classes of compound such as acids (gerbil), ketones, lactones, sulfides (golden hamster), phenolics (beaver, elephant), acetates (mouse), terpenes (elephant), butyrate esters (tamarins), among others. The human samples mentioned before contained hydrocarbons, unsaturated hydrocarbons, alcohols, acids, ketones, aldehydes, esters, nitriles, aromatics, heterocyclics, sulfur compounds, ethers, and halogenated hydrocarbons. Sulfur compounds are found in carnivores, such as foxes, coyotes, or mustelids. The major volatile compound in urine of female coyotes, Canis latrans, is methyl 3-methylhut-3-enyl sulfide, which accounts for at least 50% of all urinary volatiles (Schultz etal, 1988). 

Toxicology. At high concentrations tert-butyl alcohol causes narcosis in animals, and it is expected that severe exposure in humans will result in the same effect with repeated exposures in rodents the urinary tract is the primary target. 

N4. Nossel, H. L., The effect of moiphine on the serum and urinary amylase and the Sphincter of Oddi, with some preliminary observations on the effect of alcohol on the serum amylase and the Sphincter of Oddi. Gastroenterology 29, 409-416 (1955). 

Drugs that may affect aspirin include activated charcoal, ammonium chloride, ascorbic acid or methionine, antacids and urinary alkalinizers, carbonic anhydrase inhibitors, corticosteroids, and nizatidine. Drugs that may be affected by aspirin include alcohol, ACE inhibitors, anticoagulants (oral), beta-adrenergic blockers, heparin, loop diuretics, methotrexate, nitroglycerin, NSAIDs, probenecid and sulfinpyrazone, spironolactone, sulfonylureas and exogenous insulin, and valproic acid. 

Carbachol, being a carbamic ester and not an alcohol is a far less suitable substrate for the esterases. The indications for carbachol are glaucoma, postoperative atonic states of the urinary bladder and the gut as well as supraventricular paroxysmal tachycardia. 

Psychotic symptoms may also occur with the withdrawal of alcohol, sedatives, hypnotics, and anxiolytics The following symptoms may occur persecutory delusions, perceptual distortions, and vivid hallucinations in any modality, most classically visual and tactile hallucination of insects crawling under the skin (formication) Substance abuse history may be elicited from the history and confirmed by finding urinary metabolites Confirmation of schizophrenia can only be made if the psychotic symptoms persist for at least a month following drug withdrawal... 

Symptomatic porphyria patients usually show urinary porphyrin concentrations that exceed the upper limit of normal by twofold or more. Table 7.3.1 lists most of the diagnostic abnormalities of the different porphyrias. Only slightly abnormal or even fully normal values may be seen in asymptomatic patients. But alcohol overconsumption, enzyme-inducing drugs, stress, and other factors may also induce slightly abnormal values that should not be mistaken for porphyria. A characteristic sign for such a secondary effect is the isolated elevation of coproporphyrin, especially of its... 

In rats receiving [ Cjbenzyl chloride in corn oil by gavage, the peak plasma level was reached after 30 min. The distribution half-life was 1.3 h, while the elimination half-life was 58.5 h. After 48 h, the higher concentrations were found in the stomach, gastric contents, ileum and duodenum, followed by liver, adrenal, bone marrow and blood. After 72 h, approximately 76% was excreted in urine and, in expired air, 7% as 002 and less than 1.3% as benzyl chloride or its metabolites. Urinary metabolites were identified as Y-benzyl-A-acetyl cysteine, benzx l alcohol and benzaldehyde (Saxena Abdel-Rahman, 1989). 

Human polymorphisms in several enzymes involved in toluene metabolism are known. In Mongoloid populations, deficiency in the low form of aldehyde dehydrogenase H2 (ALDH2) is common approximately half of the Japanese population lacks this enzyme. In ALDH2-deficient exposed workers, an increased level of benzyl alcohol was found, but benzaldehyde was not detectable urinary excretion of hippurate was decreased in the deficient individuals. The CYPlAl polymorphism, alcohol consumption and smoking were all associated with decreased hippurate excretion, but the interdependence was too complex to allow detailed conclusions on the mechanisms to be drawn (Kawamoto et al., 1995). 

Xylenes are absorbed after inhalation and dermal exposure. Elimination after human exposure is rapid and mostly as urinary metabolites after oxidation to the methylbenzyl alcohols, methylbenzoic acids and their glycine and glucuronic acid conjugates. In mice inhaling /7 ra-xylene, methylhippurate accumulated in the nasal mucosa and olfactory bulb. 

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