Intolerance alcohol

A 45-year-old female being treated for a chronic UTl develops acute alcohol intolerance. Which of the following agents could have caused this intolerance ... 

The adverse effects of antiandrogens are gynecomastia, hot flushes, GI disturbances, liver function test abnormalities, and breast tenderness. GI disturbances consist of diarrhea for flutamide and bicalutamide and nausea or constipation for nilutamide. Flutamide is also associated with methemoglobinemia, whereas nilutamide causes visual disturbances (impaired dark adaptation), alcohol intolerance, and interstitial pneumonitis. 

May take without regard to food patients with achlorhydria should take with acidic beverage (orange or cranberry juice) may cause alcohol intolerance... 

The great biliary excretion of cefoperazone causes changes in bowel flora and diarrhea may often occur. Containing a 7V-methylthiotetrazole side chain, cefoperazone may also cause hypoprothrombinemia and a disulfiram-like reaction with alcohol (alcohol intolerance). This antibiotic should be avoided by patients receiving anticoagulants. 

Nilutamide (NILANDRON) Nonsteroidal LH increased T increased Combination therapy Potency spared Libido unaffected Hot flushes, breast tenderness, nausea and vomiting, blurred vision and delayed adaptation to darkness, alcohol intolerance, interstitial pneumonitis... 

In contrast to ulcerative colitis, about 50% of patients with Crohn s colitis will respond to metronidazole given for up to 3 months, although adverse effects including alcohol intolerance, and peripheral neuropathy from such prolonged therapy often limit its use. The drug is also helpful in controlling perianal and small bowel disease and it decreases the incidence of anastamotic recurrence after surgery. Other antimicrobials, particularly ciprofloxacin may also be effective. 

Transient toxic reactions to cefepime and alcohol in the inner ear have been reported (204). Alcohol intolerance needs some time to build up and has been described for up to 5 days after the ingestion of the antibiotic (205,206). It has to be kept in mind that many pharmacological formulations contain alcohol. 

Cefotetan contains the MTT group that has been asstK-i-ated with hypoprothrombinemia and alcohol intolerance. Another cephalosporin that locks these properties should be. selected for patients at ri.sk for severe bleeding or alcoholism. 

Agarwal DP, Goedde HW Alcohol metabolism, alcohol intolerance and alcoholism biochemical and pharmacogenetic approaches. Berlin, Springer-Verlag, 1990... 

Agarwal DP, Goedde HW. 1990. Alcohol Metabolism, Alcohol Intolerance and Alcoholism. Springer-Verlag Berlin. 

ACUTE HEALTH RISKS irritation of eyes, and respiratory system nausea vomiting jaundice liver damage enlarged liver high blood pressure facial flush alcohol intolerance skin rashes. 

Aside from mild or severe allergic reaction, the most commonly experienced cephalosporin toxicities are mild and temporary nausea, vomiting, and diarrhea associated with disturbance of the normal flora. Rarely, a life-threatening pseudomembranous colitis diarrhea associated with the opportunistic and toxin-producing anaerobic pathogen, Clostridium difficile, can be experienced. Rare blood dyscrasias, which can even include aplastic anemia, also are seen. Certain structural types (details below) are associated with prolonged bleeding times and an antabuse-like acute alcohol intolerance. 

Cefmetazole is a cephamycin with a nonaromatic side chain at C-7. In addition to a fairly characteristic second-generation cephalosporin antimicrobial spectrum, it possess fairly significant anti-antiaerobic activity. The ejection of its C-3 side chain leads to alcohol intolerance of the disulfuram type and prolonged clotting times. 

Despite elaims in some books and reviews, an extensive literature search failed to find any experimental or clinical evidence for an alleged disulfiram-like reaction between alcohol and nitrofurantoin. A study in healthy subjects failed to demonstrate any such interaction and a survey of the reports in the manufacturer s database also failed to find good evidence for alcohol intolerance. It is concluded that this interaction is erroneous. ... 

Alcohol intolerance (facial flushing, malaise, hypotension) has been reported in patients receiving nilutamide but not bicalutamide or flutamide. 

Several studies have described alcohol intolerance (facial flushes, malaise, hypotension) in patients taking nilutamide. " The incidence has been reported to be between 3% and 19%. " It is recommended that patients who experience this reaction should avoid drinking alcohol. ... 

Lyle WH, Spence TWM, McKinneley WM, Duckers K. Dimetiiylformamide and alcohol intolerance. BrJIndMed (1979) 36, 63-6. 

There are other reports of this interaction between tacrolimus and alcohol. The reaction is usually confined to the face and the intensity may be related to the amount of alcohol ingested. In an open study of 316 patients, alcohol intolerance (facial flushing) was observed in 19% of the patients using tacrolimus 0.1% ointment and in a controlled study, 6.9% of patients experienced the reaction with tacrolimus 0.1% ointment, and 3.4% of patients experienced the reaction with tacrolimus 0.03% ointment. ... 

The interaction between topical tacrolimus and alcohol is established and appears to occur in about 6 to 7% of patients treated with tacrolimus 0.1% ointment. Patients should be warned of the possibility of a flushing reaction with alcohol and that consumption of alcohol may need to be avoided if this occurs. Clinicians should be aware of the interaction and obtain a careful history, including alcohol use, in patients who present with new acute symptoms while using tacrolimus. It has been suggested that aspirin may possibly reduce the symptoms of this reaction, but this needs further study. Alcohol intolerance with pimecrolimus has been reported, but appears to be rare. ... 

Milingou M, Antille C, Sorg O, Saurat J-H, Liibbe J. Alcohol intolerance and facial flushing in patients treated with topical tacrolimus. Arch Dermatol (2004) 140, 1542-4. 

Chloromethane exposures from foam production caused tremor and decreased attention and ability to do arithmetic. Enviromnental exposures from leaks in refrigerating systems caused deaths, convulsions, myoclonus and personality changes. One fishing boat exposure of 15 men left profound neurological residuals, fatigue, depression and alcohol intolerance. The effects resemble those of methyl bromide poisoning. 

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