Pharmacogenetics approaches

Turecki, G., Grof, R, Grof, E. etal. (2001). Mapping susceptibility genes for bipolar disorder a pharmacogenetic approach based on excellent response to lithium. Mol. Psychiatry, 6, 570-8. 

Vermes A et al. Individualisation of cancer therapy based on cytochrome P450 polymorphism a pharmacogenetic approach. Cancer Treat Rev 1997 23 321-339. 

Drug safety is one of the first places where we are likely to see the benefits of pharmacogenetics. Pharmacogenetic approaches differ according to the rate of adverse events. Common adverse events with rates of 1% or more can be evaluated during a traditional drug development program. Com-... 

Agarwal DP, Goedde HW Alcohol metabolism, alcohol intolerance and alcoholism biochemical and pharmacogenetic approaches. Berlin, Springer-Verlag, 1990... 

Heilig M, Goldman D, Berrettini W, O Brien CP (2011) Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci 12 670-684... 

Johnson BA, Ait-Daoud N, Seneviratne C, Roache JD, Javors MA, Wang XQ, Liu L, Penberthy JK, DiClemente CC, Li MD (2011) Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking. Am J Psychiatry 168 265-275... 

The pharmacogenetics approach is very well suited to solve the problems of single-gene (Mendelian or monogenic) disorders. 

Sayers I, Hall I P (2005). Pharmacogenetic approaches in the treatment of asthma. Curr. Allergy Asthma Rep. 5 101-108. 

Cancer chemotherapy is an area that requires continual monitoring and adjustment of antineoplastic agents to achieve optimal therapeutic outcome, which makes pharmacogenetic approaches attractive in this held. 

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