Aging advanced

Denton, G. H. and Hendy, C. H. (1994). Younger Dryas age advance of Franz Josef Glacier in the Southern Alps of New Zealand. Science 264, 1434-1437... 

As with many other disease states, a significant risk factor associated with ovarian cancer is aging. A womans risk increases from 15.7% to 54% per 100,000 as her age advances from 40 to 79 years, with the mean age at diagnosis being 59 years.2... 

The dosage may be gradually titrated upward at 6- to 12-month intervals as needed to achieve appropriate bone age advancement and eventual epiphyseal closure. Chronic dosing with 0.625 mg is sufficient to induce artificial cyclic menses with sequential progestin treatment and to maintain bone mineral density after skeletal maturity is achieved. 

FIGURE 3.3 Schematic showing possible sites of intervention by carnosine during formation of cross-linked methylglyoxal-modified proteins. AGE, advanced glycation end-product. 

Some oxidative (Phase I) drug-metabolizing enzymes are already present in the human foetal liver as early as 12 weeks after conception. Others progressively appear as foetal age advances, although... 

Filogamo, G. et al., Brain plasticity Development and aging, advances in experimental medicine and biology, Vol. 429, Plenum Press, New York, 1997. 

Fig. 10.1 Cellular formation and metabolism of methylglyoxal (MG). AGEs advanced glycoxida-tion endproducts DHAP dihydroxyacetone phosphate G3P glyceraldehyde 3-phosphate F-6P fructose 6-phosphate F-1,6P2 fmctose 1,6-bisphosphate Gly-I II glyoxalase I II SSAO semicarbazide-sensitive amine oxidase AMO amine oxidase.

A. Stein, B. J. Melde, and R. C. Schroden, Hybrid inorganic-organic meso-porous silicates-nanoscopic reactors coming of age, Advanced Materials 12, 1403-1419 (2000). 

AGE advanced glycadon endproducts AZT 3 -azido thymicUne/zidovudine... 

Many people find that their mobility becomes less as their age advances. Not only do they become less robust, locomotor problems, often secondary to arthritic conditions, supervene. These further restrict the opportunities for exercise. If calorie intake is not reduced to compensate for reduced energy expenditure, weight gain is likely to ensue, sometimes to the point of frank obesity. To prevent this happening, as well as to reverse any unwanted weight gain, dietary counselling should be offered. 

Nies A, Robinson DS, Davis JM, Ravaris CL (1973) Changes in monoamine oxidase with aging, In Eisdorfer C, Fann WE (eds) Psychopharmacology of aging (Advances in behavioral biology). Plenum Press, New York, pp 41-54... 

While TMA is one of the older and simpler forms of thermal analysis, its importance is in no way diminished by its age. Advances in DSC technology and the appearance of dynamic mechanical analysis (DMA) as a common analytical tool have decreased the use of it for measuring glass transitions, but nothing else allows the measurement of CTE as readily as TMA. In addition, the ability to run standardized material test methods at elevated temperatures easily makes TMA a reasonable alternative to larger mechanical testers. As the electronic, biomedical, and aerospace industries continue to push the operating limits of polymers and their composites, this information will become even more important. During the last 5 years a major renewed interest in dilatometry and volumetric expansion has been seen. Other thermomechanical techniques will also likely be developed or modernized as new problems arise. 

AGE (advanced glycation end-product) caramel-like material formed by the reaction of a protein with glucose and oxygen. age-1 gene that when mutated extends the lifespan of nematode worms, allele one of (usually) several variants of the same gene. 

Bagchi, D. and Preuss, EI.G., Oligomeric proanthocyanidins in human health and disease prevention, in Critical Reviews in Oxidative Stress and Aging Advances in Basic Science, Diagnostics and Intervention, Cutler, R.G. and Rodriguez, H., Eds., World Scientific Publishing, NJ, 2002, p. 640. 

AGE, advanced glycation end product CML, A -carboxymethyl-L-lysine DMF, AiV-dimethylformamide DOTA, 1,4,7,10-tetraazacyclododecane-l,4,7,10-tetraacetate DTPA, diethylenetriamine pentaaeetate FAD, flavin adenine dinucleotide FN3K, fiuctosamine-3-kinase GLUTS, glucose transporter-5 GTP, guanidine triphosphate ... 

Observational studies In 2190 adults taking stavudine and nevirapine (median followup 1.5 years), stavudine had to be replaced in 175 (8.0%) because of neuropathy, in 69 (3.1%) because of lactic acidosis and in 157 (7.2%) because of Upoatrophy significant susceptibility factors associated with lactic acidosis and late neuropathy included a higher baseline body weight and older age advanced HIV disease increased the risk of neuropathy [661. 

Abbreviations 8-OH-dG, 8-hydroxy-20-deoxyguanosine AGE, advanced glycation end products GSH/GSSG, ratio of glutathione/oxidized glutathione HNE, 4-hydroxy-2-nonenal MDA, malondialdehyde NO -Tyr, 3-nitro-tyrosine... 

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