Agents and Drugs

Cholinesterase inhibitor (anti-cholinesterase, ChEI) is a chemical that prevents cholinesterases (ChEs) from breaking down. ACh, which consequently increases the level and duration of action of this neurotransmitter. ChEIs such as organophosphates (esters of phosphoric acid) and carbamates (esters of carbamic acid) - serve as insecticides, pesticides, warfare agents and drugs. 

I. A. Buryakov, Express analysis of explosives, chemical warfare agents and drugs with multicapillary column gas chromatography and ion mobility increment spectrometry, J. Chromatogr. B, 800 (2004) 75-82. 

Insel PA. (1996). Analgesic-antipyrectic and anti-inflammatory agents and drugs employed in the treatment of gout. In Goodman and Gilman s The PharmacoT... 

The steroids are a remarkable family of molecules. They are essential for health, responsible for the characteristics of our genders, useful medicinal agents, and drugs of abuse. Modest structural variations on the central theme of steroid structure profoundly alter the physiological response to the action of these molecules. Small differences in structure can create big differences in function. 

Be able to understand the unique psychopharmacological mechanisms of action of the major antidepressants, anxiolytics, antipsychotics, cognitive enhancing agents, and drugs of abuse. 

Osawa Y. and Davila J. C. (1993). Phencyclidine, a psychotomimetic agent and drug of abuse, is a suicide inhibitor of brain nitric oxide synthase. Biochem. Biophys. Res. Commun. 194 1435-1439. 

Feldman, S., M. Salvino, and M. Gibaldi. 1970. Physiologic surface-active agents and drug absorption. VII. Effect of sodium deoxycholate on phenol red absorption in the rat. J Pharm Sci 59 705. 

Humankind has reaped extraordinary benefits from the pharmacological revolution of the twentieth century. Conditions such as poliomyelitis, diphtheria and whooping cough have been largely eliminated in developed countries by immunization. Many lethal communicable diseases can be readily cured with antimicrobial agents. And drugs have improved the quality of life for many people with chronic diseases to an extent that would have been unthinkable in the nineteenth century (p. 360). 

Summary of blocking agents and drugs affecting neurotransmitter uptake or release. 

Application of microdevices to the analysis of drugs can provide important benefits for both therapeutic agents and drugs of abuse. Rapid identification of a... 

GC coupled with IMS has many advantages and is applied for quality control in the pharmaceutical industry [131, 132] and for detection of trace amount of explosives, warfare agents, and drugs [133-135]. This system is used to monitor ambient air [136] and for direct analysis of exhaled air [137]. 

Feldman, S. Gibaldi, M. Physiological surface-active agent and drug absorption 1. Effect of sodium taurodeoxycholate on salicylate transfer across the everted rat intestine. J. Pharm. Sci. 1969, 58, 425-428. 

The transdermal route provides an alternative route to oral administration. Drugs delivered by this route avoid digestion in the gastrointestinal tract (GI), local metabolism related to the GI route, and hepatic first pass metabolism. It can provide controlled drug delivery with the possibility of zero order (continuous) release. Thus, it is most suitable for short half-life therapeutic agents and drugs with narrow therapeutic windows. The use of transdermal patches is more... 

MDMA (3.4-methylenedioxymethylamphetamjne EA 1475 XTC Ecstasy E ) has amphetamine-like actions, and induces release of, and is a (re-) uptake inhibitor of 5-hydroxytryptamine. Also, it is a monoamine-oxidase INHIBITOR (MAOI, type A), slowing catabolism of 5-HT. It is a PSYCHOTROPIC AGENT and drug of abuse. 

A substance inhibiting cell growth by competing with, or substituting for, a natural substrate in an enzymatic process. Sulfonamides and trimethoprim are antimetabolites, as are many antiviral agents and drugs used in cancer chemotherapy. 

OSMOTIC AGENTS AND DRUGS AFFECTING CARBONIC ANHYDRASE... 

Sulfonamides and trimethoprim are antimetabolites, as are many antiviral agents and drugs used in cancer chemotherapy. 

Identify the chemical agents and drugs that cause parkinsonism symptoms. 

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