Incidences of Drug- and Other Agent-Induced Anaphylaxis During Anesthesia

2 Incidencesof Drug-and Other Agent-Induced Anaphylaxis During Anesthesia 

7 Drugs and Other Agents Used In Anesthesia and Surgery 

Both surveys for reactions to antibiotics reveal the p-lactam antibiotics to be the dominant culprit drugs with incidences of 86 and 88.5 % in the French and Australian figures, respectively. However, while penicillins were implicated a little more often than cephalosporins in the French experience (49-37 % of reactions to antibiotics), the number of reactions to cephalosporins in Australian patients was nearly five times as great as the penicillins figure (73.1-15.4 %). 

Adverse reactions to the penicillin and cephalosporin antibiotics, two of the clinically most important families of antimicrobial drugs but also two of the most allergenic, are examined in detail in Chap. 5 and will not be discussed further here. The opioid group of drugs are responsible for around 2 % of reactions during the perioperative period. These histamine-releasing, clinically important analgesics are dealt with separately in Chap. 8. 

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