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Alkylating Agents and Related Drugs

Alkylating agents and related compounds act by forming covalent bonds with DNA. thus impeding DNA replication. They can be divided into five subgroups (i) nitrogen mustards (e.g. chlorambucil, cyclophosphamide, melphalan and mustine (ii) platinum drugs (coordination complexes of platinum) (e.g. cisplatin and carboplatin) ... [Pg.24]

Eye. Toxic cataract can be due to chloroquine and related drugs, adrenal steroids (topical and systemic), phenothiazines and alkylating agents. Comeal opacities occur with phenothiazines and chloroquine. Retinal injury occurs with thioridazine (particularly, of the antipsychotics), chloroquine and indomethacin. [Pg.146]

Each category of chemotherapy drugs has similar side effects. Anthracyclines cause cardiac toxicity, which is related to the cumulative dose. Tubulin interactive agents are associated with neuropathy and ileus. Alkylating agents are associated with secondary malignancies. [Pg.1277]

Dihydropyrrolizines 272, their salts and solvates, were prepared and evaluated as potential antitumor drugs or as site-specific DNA alkylating agents in the gene-relating technologies <1998WO9827095>. [Pg.35]

Cytotoxic antibiotics produce their effect mainly by direct action on DNA. Anthracyclines include the important drugs doxorubicin, aclarubicin and idarubicin. Related compounds are mitozantrone and epirubicin. Some others are the Streptomyces antibiotic dactinomycin. and the metalchelating glycopeptides especially bleomycins. Mitomycin effectively is a prodrug that is converted in the body to an alkylating agent. [Pg.24]

See other pages where Alkylating Agents and Related Drugs is mentioned: [Pg.182]    [Pg.284]    [Pg.285]    [Pg.286]    [Pg.182]    [Pg.284]    [Pg.285]    [Pg.286]    [Pg.582]    [Pg.1315]    [Pg.3461]    [Pg.20]    [Pg.136]    [Pg.1790]    [Pg.132]    [Pg.154]    [Pg.83]    [Pg.161]    [Pg.1283]    [Pg.160]    [Pg.1132]    [Pg.1210]    [Pg.113]    [Pg.655]    [Pg.236]    [Pg.100]    [Pg.113]    [Pg.97]    [Pg.276]    [Pg.814]    [Pg.12]    [Pg.236]    [Pg.136]    [Pg.1040]    [Pg.391]    [Pg.395]    [Pg.22]    [Pg.153]    [Pg.1274]    [Pg.254]    [Pg.26]    [Pg.2292]    [Pg.2324]    [Pg.2549]    [Pg.233]    [Pg.157]    [Pg.58]    [Pg.861]   


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Agents and Drugs

Alkylating agents alkylation

Alkylating drugs

Alkylation agents

Drug-related

Drugs and Related Agents

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