Adrenocorticotropic hormone activity

Figure 8-8. Hormone feedback regulation. CRH = corticotropin releasing hormone ACTH = adrenocorticotropic hormone = activates = inhibits.

Taunton, O.D., Roth, J., Pastan, I. Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor. J. biol. Chem. 244, 247-253 (1969)... 

Pregnenolone is transported from the mitochondria to the ER, where a hydroxyl oxidation and migration of the double bond yield progesterone. Pregnenolone synthesis in the adrenal cortex is activated by adrenocorticotropic hormone (ACTH), a peptide of 39 amino acid residues secreted by the anterior pituitary gland. 

Otfier fiormones accelerate tfie release of free fatty acids from adipose tissue and raise tfie plasma free fatty acid concentration by increasing the rate of lipolysis of the triacylglycerol stores (Figure 25—8). These include epinephrine, norepinephrine, glucagon, adrenocorticotropic hormone (ACTH), a- and P-melanocyte-stimulat-ing hormones (MSH), thyroid-stimulating hormone (TSH), growth hormone (GH), and vasopressin. Many of these activate the hormone-sensitive hpase. For an optimal effect, most of these lipolytic processes require the presence of glucocorticoids and thyroid hormones. These hormones act in a facilitatory or permissive capacity with respect to other lipolytic endocrine factors. 

Activated partial thromboplatin time (aPTT) Adrenocorticotropic hormone (ACTH) Alanine aminotransferase (ALT, SGPT) Albumin... 

A trophic hormone acts on another endocrine gland to stimulate secretion of its hormone. For example, thyrotropin, or thyroid-stimulating hormone (TSH), stimulates the secretion of thyroid hormones. Adrenocorticotropin, or adrenocorticotropic hormone (ACTH), stimulates the adrenal cortex to secrete the hormone cortisol. Both trophic hormones are produced by the pituitary gland in fact, many trophic hormones are secreted by the pituitary. The pituitary gland is sometimes referred to as the "master gland" because its hormones regulate the activity of other endocrine glands. 

However, nicotine also has been shown to stimulate the hypothalamic-pituitary-adrenal axis in rodents, leading to elevated plasma levels of adrenocorticotropic hormone and corticosterone (Andersson et al. 1983 Cam et al. 1979), which are known to exert a wake-promoting effect. However, studies in humans have shown that only intense smoking is able to activate the hypothalamic-pituitary-adrenal axis (Gilbert et al. 1992 Kirschbaum et al. 1992). Nicotine patches, in addition to their use in nicotine suppression and craving, have been used to explore the relationship between sleep and nicotine in human... 

As would be expected of active protein secreting cells, glandular epithelial tissue, the cytokine secreting cells of the immune system and the blood vessel endothelium, have an extensive internal structure consisting of rough endoplasmic reticulum and numerous mitochondria. Peptide hormones, growth factors and cytokines like all proteins are synthesized by DNA transcription and mRNA translation. The primary transcript of the mRNA may code for an inactive prohormone which requires careful proteolysis to produce the active hormone, as for example in the case of insulin. Adrenocorticotropic hormone (ACTH) is particularly interesting in this respect because... 

The relationship between the structure of a series of peptides derived from the adrenocorticotropic hormone ACTH, and the behavioural activity in an active avoidance behaviour test, has been studied over the past 10-20 years. The results obtained were quite different from those in which endocrine activity relationships were studied. From the outcome of a quantitative study on the structure--behavioural activity of the ACTH-related peptides, suggestions about the spatial interactions at the receptor site were made. This receptor-bound conformation differed from those suggested by solution experiments or found in crystal structures. 

N-Acetylalanyl N -methylamide, 2ll3f Aclacinomycin A, 8i1,87f Acridine orange intercalator, 125f Adrenocorticotropic hormone (ACTH) D-amino acids and activity, 155-58 biological and physicochemical properties, 158-62 chain length and... 

A counterpart of evidence that CCK agonists are anxiogenic is to answer the question of whether the CCK system is functionally implicated in non-provoked symptoms of panic or anxiety. It is conceivable that endogenous variations of central and/or peripheral CCK activity may be a neurochemical concomitant of anxiety. It is interesting to mention that serum concentrations of gastrin, a CCK-B agonist, fluctuate in correlation with self-reported tension, conflict, and anxiety in psychiatrically healthy men (M. Feldman et al. 1992). Plasma CCK levels were markedly elevated in sportsmen before a competitive marathon run, as compared with CCK levels under control conditions (Phillip et al. 1992). Plasma concentrations of adrenocorticotropic hormone (ACTH), cortisol, and noradrenaline were also elevated and increased extensively after the running performance. However, CCK levels re-... 

Neuroendocrine measures (Newhouse et al. 1990] tended to confirm that the doses used were active at CNS nicotinic receptors. Adrenocorticotropic hormone and cortisol showed significant (F <. 01] dose- and time-related increases in both groups of subjects. The adrenocorticotropic hormone increase was evident by 30 minutes, with the cortisol increase being delayed until 60 minutes, suggesting no direct effect of nicotine on adrenal cortical cells. Reports of physical side effects were generally minimal, although some subjects complained of a mild headache. No consistent report of nausea was found in either group. 

Getting SJ et al Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum 2002 46 2765. [PMID 12384937]... 

Other Hormones. Pituitary hormones regulate the function of many other endocrine glands, and hypophysectomy in male rats results in a decrease in the activity of xenobiotic metabolizing enzymes. Administration of adrenocorticotropic hormone (ACTH) also results in a decrease of those oxidative enzyme activities that are gender dependent. In contrast, ACTH treatment of female rats causes an increase in aminopyrine /V-dcmcthylasc but no change in other activities. 

D2-like receptors couple mainly to Gi/o proteins, as mentioned above. However, there is no direct evidence to support this coupling for the release-modulating autoreceptors. Moreover, the subsequent intracellular signal transduction has never been studied directly in axon terminals. Mouse AtT-20 pituitary cells, which release acetylcholine and adrenocorticotropic hormone, have been used as a model for axon terminals. When expressed in these cells, D3 receptors mediated inhibition of P/Q-type calcium channels and activation of G protein-coupled inward rectifier potassium channels (Kuzhikandathil et al. 1998 Kuzhikandathil and Oxford 1999). Both would explain the autoreceptor-mediated inhibition of dopamine exocytosis. 

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