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Release modulators

It has been revealed that cannabinoids exhibit neuroprotectant activities in both in vitro and in vivo models [249]. The neuroprotective effects are mainly based on regulation of transmitter release, modulation of calcium homeostasis, anti-oxidant properties and modulation of immune responses. A number of neurological disorders, including brain trauma, cerebral ischaemia, Parkinson s disease and Alzheimer s disease represent possible therapeutic areas for cannabinoids with neuroprotective properties. Cannabinoids are also suggested to have potential against glaucoma due to their neuroprotective nature and lowering of intraocular pressure [250]. [Pg.272]

Miller A., Blaha C. (2004). Nigrostriatal dopamine release modulated by mesopontine muscarinic receptors. NeuroReport 15, 1805-8. [Pg.217]

The non-volatiles may not possess a signal value themselves but may act as release modulators, or keeper substances. The MUPs in mice provide an example. Each individual expresses at least 4 to 15 different proteins and the combination differs between individuals in the population. Most of the variation between MUPs occurs on the surface of the molecule and is accessible to chemoreceptors. MUPs are stable over the life of the individual. On urine... [Pg.29]

Rothman RB Baumarm MH (2006). Balance between dopamine and serotonin release modulates behavioral effects of amphetamine-type drugs. Annals of the New York Academy of Sciences, 1074, 245-60... [Pg.168]

Rozov A, Burnashev N, Sakmann B, Neher E (2001) Transmitter release modulation by intracellular Ca2+ buffers in facilitating and depressing nerve terminals of pyramidal cells in layer 2/3 of the rat neocortex indicates a target cell-specific difference in presynaptic calcium dynamics. J Physiol 531 807-26... [Pg.22]

D2-like receptors couple mainly to Gi/o proteins, as mentioned above. However, there is no direct evidence to support this coupling for the release-modulating autoreceptors. Moreover, the subsequent intracellular signal transduction has never been studied directly in axon terminals. Mouse AtT-20 pituitary cells, which release acetylcholine and adrenocorticotropic hormone, have been used as a model for axon terminals. When expressed in these cells, D3 receptors mediated inhibition of P/Q-type calcium channels and activation of G protein-coupled inward rectifier potassium channels (Kuzhikandathil et al. 1998 Kuzhikandathil and Oxford 1999). Both would explain the autoreceptor-mediated inhibition of dopamine exocytosis. [Pg.296]

A large receptor reserve - i.e., receptors in excess of those necessary to produce a maximum response - has been described for release-modulating dopamine autoreceptors in rat striatum (Yokoo et al. 1988). No reserve exists for the autoreceptors in human neocortex (Loffler et al. 2006). [Pg.296]

GObel I, Trendelenburg AU, Cox SL, Meyer A, Starke K (2000) Electrically evoked release of 3H-noradrenaline from mouse cultured sympathetic neurons release-modulating heteroreceptors. J Neurochem 75 2087-94... [Pg.571]

Fde dt database pmJafaon Setijj Controlecf Release Modules (Optional) Help... [Pg.235]

Pillay V, Fassihi R. In vitro release modulation from cross-linked pellets for site-specific drug delivery to the gastrointestinal tract. Part 2. Physicochemical characterization of calcium-alginate, calcium-pectinate and calcium-alginate-pectinate pellets. / Control Release 1999 59 243-256. [Pg.88]

In addition to Ca2+ influx, Ca2+ release from intracellular stores (endoplasmic reticulum) also participates in its physiological functions (Prentki et al., 1984a). It appears, however, that this intracellular release modulates... [Pg.82]

Losi, E., Bettini, R., Santi, R, Sonvico, R, Colombo, G., Lofthus, K., Colombo, P. and Peppas, N.A. (2006) Assemblage of novel release modules for the development of adaptable drug delivery systems. 1 Control Release, 111, 212-218. [Pg.244]

File Edit Database Slrrulatlon Setup Controlled Release Modules (OpdoraQ... [Pg.225]

File Edit SimutaClon Setup Controlled Release Modules (Optlond) Help... [Pg.226]

File Edit Database SmLilabon Setup Controlled Release Modules (Optional) Hdp... [Pg.226]

File Edit Database Simulation Setup on.trdlled Release Modules (OpbonaD Help... [Pg.462]

Fie Edit Sim JatiDn G ntroled Release Modules (Optional) hlelp... [Pg.463]

See other pages where Release modulators is mentioned: [Pg.100]    [Pg.142]    [Pg.22]    [Pg.171]    [Pg.333]    [Pg.390]    [Pg.570]    [Pg.311]    [Pg.385]    [Pg.428]    [Pg.102]    [Pg.140]    [Pg.196]    [Pg.196]    [Pg.196]    [Pg.39]    [Pg.97]    [Pg.97]    [Pg.442]    [Pg.244]   
See also in sourсe #XX -- [ Pg.29 ]



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Controlled release systems enzyme-modulated

Enzymes polymer controlled release modulated

Modulated release

Modulated release

Modulation of ACh release

Modulation of Release and Formulations

Presynaptic modulation of transmitter release

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