Mutagenicity acrolein

Smith RA, Cohen SM, Lawson TA. 1990. Acrolein mutagenicity in the V79 assay. Carcinogenesis 11 497-498. 

Marsden, P.J. Casida, J.E. (1982) 2-Haloacrylic acids as indicators of mutagenic 2-halo-acrolein intermediates in mammalian metabolism of selected promutagens and carcinogens. 

Nelson, S.D., Omichinski, J.G., Lyer, L., Gordon, W.P, Soderhmd, E.J. Ebbing, E. (1984) Activation mechanism of tris(2,3-dibromopropyl) phosphate to the potent mutagen, 2-bromo-acrolein. Biochem. Biophys. Res. Commun., 121, 213-219... 

Genotoxic Effects. No studies were located regarding the genotoxic effects of acrolein in humans or animals by inhalation, oral, or dermal routes. Acrolein was not mutagenic in vivo as judged by the dominant lethal assay in the mouse (Epstein et al. 1972) or the sex-linked recessive lethal test in... 

Genotoxicity. No studies were located regarding acrolein genotoxicity in humans. Dominant lethality of acrolein observed in mice indicated a genotoxic potential in mammals. The result is supported by in vitro data that showed mutagenic potential of acrolein in bacterial and mammalian cells without metabolic activation. Further studies in animals would be useful to determine the ability of acrolein to induce chromosomal aberrations after exposure. Cytogenetic analysis of peripheral lymphocytes of workers exposed to acrolein would provide an opportunity to assess its genotoxicity in humans. 

Basu AK, Marnett LJ. 1984. Molecular requirements for the mutagenicity of malondialdehyde and related acroleins. Cancer Res 44 2848-2854. 

Flales BF. 1982. Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein. Cancer Res 42 3016-3021. 

Interest in the toxicity7 of aldehydes has focused primarily on specific compounds, particularly formaldehyde, acetaldehyde, and acrolein (13). Little evidence exists to suggest that occupational levels of exposure to aldehydes would result in mutations, although some aldehydes are clearly mutagenic in some test systems. There are, however, acute effects of aldehydes. 

Oxidation of Glycidol. Glycidol is oxidized to glycidic acid with Ruthenium(VIII) Oxide Glycidaldehyde is a mutagenic compound that has been prepared in racemic form by epoxida-tion of Ac role in and in nonracemic forms by the degradation of mannitol. Alternately, (R)- and (5)-glycidaldehyde may be prepared and handled more conveniently via asymmetric dihydroxy lation of acrolein benzene-1,2-dimethanol acetal followed by conversion of the diol to an epoxide (see eq 28). ... 

When tested in the Salmonella assay, acrolein was weakly positive. It was not mutagenic in the dominant lethal assay in the mouse and in the Drosophila sex-linked recessive lethal test, and negative for chromosome aberrations when tested in cultured Chinese hamster ovary cells however, there was an increase in the frequency of sister-chromatid exchanges. 

R. S. (2008) Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts. Mutat. Res., 637, 161-172. 

MDA and 3-substituted acroleins are mutagenic in several tester strains of Salmonella typhimurium. The strain sensitivity of mutation indicates that adducts formed from these bifunctional electrophiles induce base-pair substitutions, are repaired by nucleotide excision repair (NER), and require the action of translesion DNA polymerases (Pol II, IV, or V) to induce mutations. Interestingly, MDA induces frameshift mutations in Salmonella, whereas acrolein, crotonaldehyde, and 4-hydroxy-2-nonenal do not [103-106],... 

Mutagen Substance capable of causing a heritable change in the genetic information stored in the DNA. Many chemicals, including imines, epoxides, acrolein, benzene, sulfur, and methylsulfonates, are mutagens. Mutagens can cause fertility... 

Acrolein was mutagenic to certain microorganisms and to the fruit fly mutagenicity may be due, in part, to glycidaldehyde, an acrolein metabolite. Injected into the amniotic fluid, acrolein is teratogenic to rats teratogenicity may be due to acrylic acid, another acrolein metabolite. There is limited evidence that acrolein acts as a weak carcinogen and tumor promoter. Acrolein interacts with other... 

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