Porphyria cutanea tarda PCT

If a patient presents with blisters due to photosensitivity, a plasma scan and fecal porphyrins will not only reveal the presence of a porphyria, but will also enable the distinction between the three forms that may cause such symptoms porphyria cutanea tarda (PCT), PV, and HC. Urinary porphyrins and eventually quantitative ALA und PBG in urine may be added in questionable cases or for monitoring of therapy. 

Porphyria cutanea tarda PCT Uroporphyrinogen tit decarboxylase autosomal dominant... 

Among the drug-induced photosensitivity diseases, different variants of the porphyrias are best known (Rimington, 1989 Thunell, 2000). Porphyria cutanea tarda (PCT) can be induced or aggravated by chlorophenols, estrogens, ethanol, hexa-chlorobenzene, and 2-benzyl-4,6-dichlorophenol. 

Now that we have considered the properties of ALA-synthetase, its synthesis and control, and the other factors that affect its activity, let us see how we may explain the symptoms of the hepatic porphyrias. There are two major forms of the disease acute intermittent porphyria (AIP) and porphyria cutanea tarda (PCT) [6,11]. In Table V are listed... 

HMBS hydroxymethylbilane-synthase, Intermediaries heptacarboxy-, hexacarboxy-and pentacarboxyporphyrins, MIM Nr Mendelian Inheritance in Man number, PCT porphyria cutanea tarda, Proto protoporphyrin IX, PV porphyria variegata, Uro uroporphyrin... 

The nonacute porphyrias include PCT, CEP, and EPP. Porphyria Cutanea Tarda... 

Figure 44-3. Heme biosynthetic pathway and characteristics associated with specific enzyme-deficiency porphyrias. ADP = ALA dehydratase deficiency porphyria AIP = acute intermittent porphyria CEP = congenital erythropoietic porphyria PCT = porphyria cutanea tarda HEP = hepatoerythropoietic porphyria HCP = hereditary coproporphyria VP = variegate porphyria EPP = erythropoietic protoporphyria.

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