Zebrafish

Live vertebrate animal with high degree of genetic and physiologic similarity to mammals. [Pg.111]

Small embryos/larvae can be arrayed in multiweU plates, and compounds added to culture plate wells are absorbed through exposed surfaces and gills (this unfortunately can make compound uptake variable but is no different than any other culture systems). [Pg.111]

Transparency enables visualization of multiple phenotypes and morphological changes by inverted phase microscopy either through expert technical assessment or automation. [Pg.111]

High fecundity and rapid external development allow for quick generation of embryonic and larval zebrafish for experimentation, especially since most major organs are established by 5-day postfertihzation (dpf). [Pg.111]

Development of toxic responses to a number of drugs/ small molecules comparable to mammals (endocrine disruption, reproductive and developmental toxicity, behavioral defects, carcinogenesis, cardiotoxicity, hepatotoxicity, neurotoxicity, and ototoxicity, to name a few). [Pg.111]

Zebrafish Brachydanio rerio) MMTC 96-h LC50 >102 >102 Hooftman de Woif (2003b)... [Pg.34]

Zebrafish Brachydanio rerio) MMT(EHMA) 96-h LC50 >6 >1.9 Migchieisen (2004a)... [Pg.34]

Zebrafish Brachydanio rerio) DMTC 96-h LC50 >100 >100 Hooftman de Wolf (2003d)... [Pg.35]

Zebrafish (Brachydanio rerio) DBTL 96-h LCso >saturated solution ( 2 mg/l) >saturated solution ( 1 mg/l) Schering AG (1998c)... [Pg.36]

Zebrafish (Brachydanio rerio) DBTM 96-h LCso >5.7 >5.7 Hooftman de Wolf (2003f)... [Pg.36]

Zebrafish Brachydanio rerio) MOTC 96-h LC50 >solubility limit (0.3 mg/l) >solubility limit (0.3 mg/l) Schering AG (1998g)... [Pg.37]

Zebrafish Brachydanio rerio) DOTC 96-h LCso >0.24 >0.24 Hooftman de Wolf (2003h)... [Pg.38]

Zebrafish Brachydanio rerio) DOT(EHMA) 96-h LCso >24.8 >13.6 Migchielsen (2004c)... [Pg.38]

Billsson, K., Westerlund, L., Tysklind, M., and Olsson, P.-E. (1998). Developmental disturbances caused by polychlorinated biphenyls in zebrafish (Brachydanio rerio). Marine Environmental Research 46, 461 64. [Pg.339]

Hill, R.L. and Janz, D.M. (2003). Developmental estrogenic exposure in zebrafish (Danio rerio) I. Effects on sex ratio and breeding success. Aquatic Toxicology 63, 417 29. [Pg.352]

Kazeto, Y., Place, A.R., and Trant, J.M. (2004). Effects of endocrine disrupting chemicals on the expression of CYP19 genes in zebrafish (Danio n no) juveniles. Aquatic Toxicology 69, 25-34. [Pg.355]

Legler, J., Broekhof, J.L.M., and Brouwer, A. et al. (2000). A novel in vivo bioassay for (xeno-)estrogens using transgenic zebrafish. Environmental Science and Technology 34, 4439 444. [Pg.357]

Om, S., Holbech, H., and Madsen, T.H. et al. (2003). Gonad development and vitellogenin production in zebrafish (Danio rerio) exposed to ethinylestradiol and methyltestoster-one. Aquatic Toxicology 65, 397-411. [Pg.363]

Santos, E.M., Pauli, G.C., and Van Look, K.J.W. (2007). Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio). Aquatic Toxicology 83, 134—142. [Pg.367]

Strmac, M. and Braunbeck, T. (1999). Effects of triphenyltin acetate on survival, hatching success, and liver ultrastructure of early life stages of zebrafish (Danio rerio). Ecotoxicology and Environmental 44, 25-39. [Pg.369]

Westerlund, L., Billsson, K., and Andersson, P.L. et al. (2000). Early life stage mortality in zebrafish (Danio rerio) following maternal exposnre to polychlorinated biphenyls and estrogen. Environmental Toxicology and Chemistry 19, 1582-1588. [Pg.374]

Lapidot T, Dar A, KoUet O (2005) How do stem cells find their way home Blood 106 1901-1910 Li Q, Shirabe K, Kuwada JY (2004) Chemokine signaling regulates sensory cell migration in zebrafish. Dev Biol 269 123-136... [Pg.216]

Nair S, Schilling TF (2008) Chemokine signaling controls endodermal migration during zebrafish gastrulation. Science 322 89-92... [Pg.217]

For the synthesis of drosopterin, tetrahydrobiopterin, sepiapterin, 7-oxopterin and isoxanthopterin, DHN-TP is first converted to the common intermediate 6-pyruvoyl-tetrahydropterin. The biosynthesis of pteridines was studied in zebrafish in relation with the differentiation of neural crest derivatives. The key intermediate in the synthesis of 7-oxobiopterin is the sepiapterin. Pteridins are produced in xanthophores and erythrophores of fish and amphibian species. [Pg.108]

Ziegler, L, The pteridine pathway in zebrafish regulation and specification during the determination of neural crest cell-fate, Pigment. Cell Res., 16, 172, 2003. [Pg.120]

Ziegler, I. et al.. Development of the pteridine pathway in the zebrafish, Danio rerio, J. Biol. Chem., 275, 18926, 2000. [Pg.121]

Hansen A. and Zeiske E. (1998). The peripheral olfactory organ of the zebrafish, Danio rerio an ultrastructural study. Chem Senses 23, 39-48. [Pg.210]

Holland, P. W. H. (1991). Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian. Gene 98 253-257. [Pg.120]

Reik I don t know. One thing we could do is look phylogenetically to see what the distribution of this phenomenon is versus the distribution of imprinting, for example. The data points are very sparse. In the zebrafish, which doesn t have imprinting, this doesn t happen, even though the zebrafish still needs to activate its paternal embryonic genome at some stage. [Pg.32]

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