Zebrafish development identification

Prasch AL, Tanguay RE, Mehta V, Heideman W, Peterson RE (2006) Identification of zebrafish ARNTl homologs 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the developing zebrafish requires ARNTl. Mol Pharmacol 69 776-787... 

The zebrafish embryo teratogenicity assay Fetal development/malformations/lethality Hazard identification of embryotoxicants... 

Griffin, K., Amacher, S., Kimmel, C., and Kimelman, D. (1998) Molecular identification of spadetail regulation of zebrafish trunk and tail mesoderm formation by T-box genes. Development 125,3379-3388. 

Reifers, F, Bohli, H Walsh, E., Crossley, R, Stainer, D., and Brand, M. (1998) Fgf 8 is mutated in zebrafish acerebellar mutants and is required for maintenance of midbrain-hindbrain devlopment and somitogenesis. Development 125,2381-2395. Haffter, P Granato, M., Brand, M., Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., et al. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123,1-36. 

LUO D, HU w, CHEN s, XIAO Y, SUN Y and ZHU z (2009) Identification of differentially expressed genes between cloned and zygote-developing zebrafish (Danio rerio) embryos at the dome stage using suppression subtractive hybridization. Biol Reprod, 80, 674-684. 

Past theories have identified the limits of ectoderm in the mouth as central to the determination of where teeth develop (Jollie 1968 cf. Smith and Coates 1998, fig. 8). However, this view takes no account of the widespread occurrence of denticulated plates deep within the pharynx of non-tetrapod vertebrates. These include a major, successful, group of teleosts which feed entirely as pharyngognaths, and have teeth only on the last gill arch. The model animal for developmental research in fish, the zebrafish, is one of these, and we predict that experimental data will show that this is an endodermally derived pattern. Moreover, one direction for future comparative research in all appropriate model taxa could be towards the identification of those genes which are expressed in, and give pattern and positional information to, the endoderm in relation to initiation of the dentition. Already, we know that endoderm is essential for tooth formation in amphibians, and snspect that it may be so for other gnathostomes. Finally, it shonld be possible to examine where the boundary forms between ectoderm and endoderm, and the role of this bonndary in setting up positional information for the dentition. 

Haffter P et al (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123 1-36... 

MiTRA s, ALNABULSi A, SECOMBES CJ, BIRD s (2010), Identification and characterization of the transcription factors involved in T-ceU development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio , EEBS J, 277,128-47. 

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